School of Biological and Environmental Sciences, Liverpool John Moores University, Liverpool L3 3AF, UK.
Genes (Basel). 2021 May 30;12(6):843. doi: 10.3390/genes12060843.
Genomics has revolutionised the study of the biology of parasitic diseases. The first Eukaryotic parasite to have its genome sequenced was the malaria parasite . Since then, genomics has continued to lead the way in the study of the genome biology of parasites, both in breadth-the number of species' genomes sequenced-and in depth-massive-scale genome re-sequencing of several key species. Here, we review some of the insights into the biology, evolution and population genetics of gained from genome sequencing, and look at potential new avenues in the future genome-scale study of its biology.
基因组学彻底改变了寄生虫生物学的研究方式。第一个完成基因组测序的真核寄生虫是疟原虫。从那时起，基因组学就在寄生虫的基因组生物学研究方面不断引领潮流，无论是广度（测序的物种基因组数量）还是深度（对几个关键物种进行大规模基因组重测序）。在这里，我们回顾了从基因组测序中获得的有关生物学、进化和群体遗传学的一些见解，并探讨了未来在寄生虫生物学的全基因组研究方面的潜在新途径。
