Lora Isabella, Massignani Mattia, Stefani Annalisa, Gottardo Flaviana
Department of Animal Medicine, Production and Health, University of Padova, Viale dell'Università 16, 35020 Legnaro (Padova), Italy.
Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università 10, 35020 Legnaro (Padova), Italy.
Animals (Basel). 2021 May 28;11(6):1597. doi: 10.3390/ani11061597.
This study aimed at investigating the benefits of using a drug combining ceftiofur and ketoprofen in a single injection on dairy cow welfare in the case of inflammatory disease with pyrexia, such as acute puerperal metritis (APM). Cows of an Italian dairy farm were examined between 5 and 14 days of calving: those with APM were randomly treated either with combined ceftiofur-ketoprofen (CD) or ceftiofur alone (C), starting from Day 0, and an equal number of healthy cows served as a control (CTR). Clinical examination and blood sampling were performed until Day 7 in each group according to specific schedules. Daily cow activity was recorded until Day 14 and daily milk production until Day 30. Additional data on fertility were collected until 120 days in milk (DIM). Data of 20 cows per group were analyzed. Body temperature and haptoglobin concentration dropped between Day 0 and 4 in both CD and C, approaching the level of CTR. The cure rate at Day 7 (body temperature < 39.0 °C) was 65 (CD) and 55% (C), without statistical difference. Neither cow activity nor milk production differed among the three groups. Reproductive performances in both CD and C were similar to CTR, but CD cows were 2.8 times more likely to be pregnant within 120 DIM than C, becoming pregnant about 14 days sooner. Both treatments (CD and C) have been effective in bringing the cows back to health conditions (CTR), and further studies would be needed to confirm the positive effect observed for CD on days open of the affected cows.
本研究旨在调查在患有发热性炎症疾病（如急性产后子宫炎，APM）的情况下，单次注射头孢噻呋和酮洛芬联合药物对奶牛福利的益处。对意大利一家奶牛场的奶牛在产犊后5至14天进行检查：患有APM的奶牛从第0天开始随机接受头孢噻呋 - 酮洛芬联合治疗（CD）或仅接受头孢噻呋治疗（C），并且数量相等的健康奶牛作为对照（CTR）。根据特定时间表，在每组中持续到第7天进行临床检查和采血。记录奶牛每日活动直至第14天，记录每日产奶量直至第30天。收集关于繁殖力的额外数据直至产奶120天（DIM）。对每组20头奶牛的数据进行分析。在CD组和C组中，体温和触珠蛋白浓度在第0天至第4天之间均下降，接近CTR组水平。第7天（体温<39.0°C）的治愈率在CD组为65%，在C组为55%，无统计学差异。三组之间奶牛活动和产奶量均无差异。CD组和C组的繁殖性能均与CTR组相似，但CD组奶牛在120 DIM内怀孕的可能性是C组的2.8倍，怀孕时间提前约14天。两种治疗方法（CD和C）都有效地使奶牛恢复到健康状态（CTR），需要进一步研究来证实观察到的CD对受影响奶牛空怀天数的积极作用。
