Department of Medical Engineering and Mechatronics, Ulm University of Applied Sciences, Albert-Einstein-Allee 55, D-89081 Ulm, Germany.
Medicina (Kaunas). 2022 May 27;58(6):721. doi: 10.3390/medicina58060721.
: Cataract is a disease that is globally prevalent in today's population and occurs mostly in the elderly. It is an opacity of the lens that worsens vision and can lead to blindness. One well-known risk factor of cataract is ultraviolet (UV) radiation. However, increasing exposure to modern artificial light sources like light emitting diodes (LEDs) and displays might have an impact on cataract formation due to possible high (and hidden) blue radiation. An ex-vivo study indicates that intense blue radiation causes cataract in porcine lenses. The goal of this work is the investigation whether violet or red light also lead to cataract formation in porcine lenses and to compare the impact of the different wavelengths. : LEDs with wavelengths of 407 nm (violet), 463 nm (blue) and 635 nm (red) are used to irradiate ex-vivo porcine lenses with a dose of 6 kJ/cm. Before and after irradiation the lens transmissions are measured and dark field images are taken to determine cataract formation. The same procedure is performed for unirradiated controls. : The results of the transmission measurements are in accordance with the results of the dark field images and state that 635 nm (red) is inducing no or only weak cataract. In comparison to the dark field images the transmission measurements exhibit stronger cataract formation for 407 nm than for 463 nm irradiation while the dark field images show similar cataract formation for both wavelengths. : Visible light of short wavelengths cause cataract formation in porcine eyes, and it cannot be excluded that these wavelengths, which are emitted by modern LED illuminants, also pose a danger to human eyes.
白内障是一种在当今全球人口中普遍存在的疾病，主要发生在老年人中。它是晶状体的不透明度，会导致视力下降，并可能导致失明。白内障的一个众所周知的风险因素是紫外线（UV）辐射。然而，由于可能存在高（且隐藏）蓝光辐射，现代人工光源（如发光二极管（LED）和显示器）的接触增加可能会对白内障的形成产生影响。一项离体研究表明，强烈的蓝光会导致猪晶状体白内障。这项工作的目的是研究紫光或红光是否也会导致猪晶状体白内障，并比较不同波长的影响。
使用波长为 407nm（紫光）、463nm（蓝光）和 635nm（红光）的 LED 以 6kJ/cm 的剂量辐照离体猪晶状体。辐照前后测量晶状体的透射率，并拍摄暗场图像以确定白内障的形成。对未经辐照的对照进行相同的处理。
透射率测量的结果与暗场图像的结果一致，表明 635nm（红光）不会引起或仅引起轻微的白内障。与暗场图像相比，407nm 辐照引起的白内障比 463nm 辐照更强，而暗场图像显示两种波长的白内障形成相似。
短波长可见光会导致猪眼白内障形成，不能排除这些由现代 LED 照明器发出的波长也会对人眼构成危险。
