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基于多壁碳纳米管和具有抗菌特性的纳米颗粒的杂化材料

Hybrid Materials Based on Multi-Walled Carbon Nanotubes and Nanoparticles with Antimicrobial Properties.

作者信息

David Madalina Elena, Ion Rodica-Mariana, Grigorescu Ramona Marina, Iancu Lorena, Holban Alina Maria, Nicoara Adrian Ionut, Alexandrescu Elvira, Somoghi Raluca, Ganciarov Mihaela, Vasilievici Gabriel, Gheboianu Anca Irina

机构信息

National Institute for Research & Development in Chemistry and Petrochemistry - ICECHIM, 060021 Bucharest, Romania.

Doctoral School of Materials Engineering Department, Valahia University of Targoviste, 130004 Targoviste, Romania.

出版信息

Nanomaterials (Basel). 2021 May 27;11(6):1415. doi: 10.3390/nano11061415.

DOI:10.3390/nano11061415
PMID:34072004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8228541/
Abstract

In this study, multi-walled carbon nanotubes (MWCNTs) were decorated with different types of nanoparticles (NPs) in order to obtain hybrid materials with improved antimicrobial activity. Structural and morphological analysis, such as Fourier transformed infrared spectroscopy, Raman spectroscopy, X-ray diffraction, transmission electron microscopy, environmental scanning electron microscopy/energy-dispersive X-ray spectroscopy and the Brunauer-Emmett-Teller technique were used in order to investigate the decoration of the nanotubes with NPs. Analysis of the decorated nanotubes showed a narrow size distribution of NPs, 7-13 nm for the nanotubes decorated with zinc oxide (ZnO) NPs, 15-33 nm for the nanotubes decorated with silver (Ag) NPs and 20-35 nm for the nanotubes decorated with hydroxyapatite (HAp) NPs, respectively. The dispersion in water of the obtained nanomaterials was improved for all the decorated MWCNTs, as revealed by the relative absorbance variation in time of the water-dispersed nanomaterials. The obtained nanomaterials showed a good antimicrobial activity; however, the presence of the NPs on the surface of MWCNTs improved the nanocomposites' activity. The presence of ZnO and Ag nanoparticles enhanced the antimicrobial properties of the material, in clinically relevant microbial strains. Our data proves that such composite nanomaterials are efficient antimicrobial agents, suitable for the therapy of severe infection and biofilms.

摘要

在本研究中，为了获得具有增强抗菌活性的杂化材料，用不同类型的纳米颗粒（NPs）对多壁碳纳米管（MWCNTs）进行了修饰。采用了结构和形态分析方法，如傅里叶变换红外光谱、拉曼光谱、X射线衍射、透射电子显微镜、环境扫描电子显微镜/能量色散X射线光谱以及布鲁诺尔-埃米特-泰勒技术，以研究纳米颗粒对纳米管的修饰情况。对修饰后的纳米管分析表明，纳米颗粒的尺寸分布较窄，用氧化锌（ZnO）纳米颗粒修饰的纳米管为7 - 13纳米，用银（Ag）纳米颗粒修饰的纳米管为15 - 33纳米，用羟基磷灰石（HAp）纳米颗粒修饰的纳米管为20 - 35纳米。如水分散纳米材料随时间的相对吸光度变化所示，所有修饰后的多壁碳纳米管在水中的分散性均得到改善。所获得的纳米材料显示出良好的抗菌活性；然而，多壁碳纳米管表面纳米颗粒的存在提高了纳米复合材料的活性。在临床相关微生物菌株中，氧化锌和银纳米颗粒的存在增强了材料的抗菌性能。我们的数据证明，此类复合纳米材料是有效的抗菌剂，适用于严重感染和生物膜的治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/792d4ea06b12/nanomaterials-11-01415-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/a77e09cac101/nanomaterials-11-01415-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/d39a034e64e9/nanomaterials-11-01415-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/2b92dd269bdb/nanomaterials-11-01415-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/fa08bb7b8300/nanomaterials-11-01415-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/e025aec63fdd/nanomaterials-11-01415-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/4752dc5cf83c/nanomaterials-11-01415-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/1e1f8c067e41/nanomaterials-11-01415-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/792d4ea06b12/nanomaterials-11-01415-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/a77e09cac101/nanomaterials-11-01415-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/88d020368bff/nanomaterials-11-01415-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/6a5c9af387f9/nanomaterials-11-01415-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/a231e8a1ea7b/nanomaterials-11-01415-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/acae6571bdd2/nanomaterials-11-01415-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/158355ea518d/nanomaterials-11-01415-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/78da28402332/nanomaterials-11-01415-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/d39a034e64e9/nanomaterials-11-01415-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/2b92dd269bdb/nanomaterials-11-01415-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/fa08bb7b8300/nanomaterials-11-01415-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/e025aec63fdd/nanomaterials-11-01415-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/4752dc5cf83c/nanomaterials-11-01415-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/1e1f8c067e41/nanomaterials-11-01415-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce8f/8228541/792d4ea06b12/nanomaterials-11-01415-g014.jpg

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