Laboratory of Physiopharmacology, GENCOR, University of Antwerp, 2610 Antwerp, Belgium.
Research Group Cardiovascular Diseases, GENCOR, University of Antwerp, 2610 Antwerp, Belgium.
Viruses. 2021 May 27;13(6):1003. doi: 10.3390/v13061003.
Myocarditis is an inflammatory disease of the heart with viral infections being the most common aetiology. Its complex biology remains poorly understood and its clinical management is one of the most challenging in the field of cardiology. Toll-like receptors (TLRs), a family of evolutionarily conserved pattern recognition receptors, are increasingly known to be implicated in the pathophysiology of viral myocarditis. Their central role in innate and adaptive immune responses, and in the inflammatory reaction that ensues, indeed makes them prime candidates to profoundly affect every stage of the disease process. This review describes the pathogenesis and pathophysiology of viral myocarditis, and scrutinises the role of TLRs in every phase. We conclude with directions for future research in this field.
心肌炎是一种以病毒感染为最常见病因的心脏炎症性疾病。其复杂的生物学特性仍未被充分理解，其临床管理是心脏病学领域最具挑战性的问题之一。Toll 样受体（TLRs）是一组进化上保守的模式识别受体，越来越多地被认为与病毒性心肌炎的病理生理学有关。它们在先天和适应性免疫反应中的核心作用，以及随之而来的炎症反应，使它们成为影响疾病过程各个阶段的主要候选者。这篇综述描述了病毒性心肌炎的发病机制和病理生理学，并详细研究了 TLRs 在各个阶段的作用。最后，我们为该领域的未来研究方向提出了建议。
