Olennikov Daniil N, Nikolaev Vyacheslav M, Chirikova Nadezhda K
Laboratory of Medical and Biological Research, Institute of General and Experimental Biology, Siberian Division, Russian Academy of Science, 670047 Ulan-Ude, Russia.
Department of the Adaptation Mechanisms Study, Yakutsk Scientific Center of Complex Medical Problems, 677000 Yakutsk, Russia.
Antioxidants (Basel). 2021 May 27;10(6):863. doi: 10.3390/antiox10060863.
Adams' rhododendron ( Rehder) or Sagan Dalya tea is a famous Siberian evergreen medical plant of the Ericaceae family used in traditional medicines of Buryats, Yakuts, and Mongols as a tonic, stimulant, and adaptogenic drug. The high popularity of coupled with poor scientific knowledge prompted the addressing of gaps related to metabolic and biomedical data of Sagan Dalya tea. The application of solid-phase extraction and liquid chromatography-mass spectrometric techniques for the metabolomic study of leaf extracts resulted in the identification of more than 170 compounds, including carbohydrates, organic acids, simple phenol glycosides, triterpene glycosides, flavonoids, prenylated phenols, benzoic acid derivatives, hydroxycinnamates, dihydrochalcones, catechins, and procyanidins, most of which were identified for the first time in the plant. Extended surveys of the seasonal content of all detected compounds prove that specific metabolite variations reflect the bioactivity of extracts. Regarding in vitro methods, the expressed antioxidant potential of extracts was investigated via radical-scavenging, nitric oxide scavenging, and ferrous (II) ion chelating assays. The animal-based swimming to exhaustion test demonstrates the stimulating influence of extract on physical performance and endurance, concluding that the drug could act as an adaptogen. Thus, Sagan Dalya tea () has confirmed its "old" application as a tonic remedy and requires further precise study as a novel adaptogenic plant.
亚当斯杜鹃（雷德尔）或萨甘·达利亚茶是一种著名的西伯利亚常绿药用植物，属于杜鹃花科，被布里亚特人、雅库特人和蒙古人的传统医学用作滋补剂、兴奋剂和适应原药物。其高知名度与科学知识匮乏促使人们填补与萨甘·达利亚茶代谢和生物医学数据相关的空白。采用固相萃取和液相色谱 - 质谱技术对叶片提取物进行代谢组学研究，鉴定出170多种化合物，包括碳水化合物、有机酸、简单酚糖苷、三萜糖苷、黄酮类化合物、异戊烯基化酚、苯甲酸衍生物、羟基肉桂酸、二氢查耳酮、儿茶素和原花青素，其中大多数是首次在该植物中鉴定出来的。对所有检测到的化合物的季节性含量进行的扩展调查证明，特定代谢物的变化反映了提取物的生物活性。关于体外方法，通过自由基清除、一氧化氮清除和亚铁（II）离子螯合试验研究了提取物的抗氧化潜力。基于动物的游泳至疲劳试验表明提取物对身体性能和耐力有刺激作用，得出该药物可作为适应原的结论。因此，萨甘·达利亚茶（）已证实其作为滋补剂的“古老”应用，并且作为一种新型适应原植物需要进一步精确研究。
