Olennikov Daniil N
Laboratory of Medical and Biological Research, Institute of General and Experimental Biology, Siberian Division, Russian Academy of Science, 6 Sakhyanovoy Street, Ulan-Ude 670047, Russia.
Plants (Basel). 2020 Nov 12;9(11):1555. doi: 10.3390/plants9111555.
Hemp nettle ( Boenn.) is a synanthropic species of the Lamiaceae family that is widely distributed across Europe, Asia, and Siberia. is deeply embedded in the ethnomedical tradition of Asian healers; however, this plant is still poorly characterized, both chemically and pharmacologically. To study Siberian populations of , we used high-performance liquid chromatography with photodiode array and electrospray triple quadrupole mass detection for metabolic profiling. Ninety compounds were identified, including iridoid glycosides, phenylethanoid glycosides, hydroxycinnamates, and flavone glycosides, most of which were identified in for the first time, while some phenolics were found to have potential chemotaxonomic significance in the Lamiaceae family and genus. An unequal quantitative distribution of the selected metabolites was observed within separate organs of the plant, characterized by high accumulation of most compounds within the aerial part of the plant (leaves, flowers). Analysis of the content of specific chosen compounds within the leaves of different populations of from Eastern Siberia revealed the existence of two chemical types based on metabolic specifics: the southern type accumulates flavone glucuronides, while the northern type tends to accumulate high levels of phenylpropanoids and acylated flavone glucosides. The first study of the bioactivity of extract demonstrated that the herb has low toxicity in acute experiments and expresses antioxidant potential against free radicals in the form of DPPH˙, ABTS˙, and superoxide radical, as well as high ferric reducing antioxidant power, oxygen radical absorbance capacity, and protective action in the carotene bleaching assay. In general, our results suggest the herb of as a new, prospective synanthropic plant for medical application.
麻叶荨麻（Boenn.）是唇形科的一种伴人植物，广泛分布于欧洲、亚洲和西伯利亚。它深深融入了亚洲治疗师的民族医学传统；然而，这种植物在化学和药理学方面的特征仍然很不明确。为了研究西伯利亚的麻叶荨麻种群，我们使用了配有光电二极管阵列和电喷雾三重四极杆质量检测的高效液相色谱法进行代谢物谱分析。鉴定出了90种化合物，包括环烯醚萜苷、苯乙醇苷、羟基肉桂酸酯和黄酮苷，其中大多数是首次在麻叶荨麻中鉴定出来的，同时发现一些酚类物质在唇形科和麻叶荨麻属中具有潜在的化学分类学意义。在麻叶荨麻植物的不同器官中观察到所选代谢物的定量分布不均，其特征是大多数化合物在植物地上部分（叶、花）中高度积累。对东西伯利亚不同种群麻叶荨麻叶片中特定选定化合物含量的分析表明，基于代谢特征存在两种化学类型：南方类型积累黄酮葡糖醛酸苷，而北方类型倾向于积累高水平的苯丙烷类化合物和酰化黄酮糖苷。对麻叶荨麻提取物生物活性的首次研究表明，该草药在急性实验中毒性较低，并以DPPH˙、ABTS˙和超氧阴离子自由基的形式表现出对自由基的抗氧化潜力，以及高的铁还原抗氧化能力、氧自由基吸收能力和在胡萝卜素漂白试验中的保护作用。总的来说，我们的结果表明麻叶荨麻这种草药是一种新的、有前景的用于医学应用的伴人植物。
