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INIA P572的益生菌特性及功能特性

Probiotic and Functional Properties of INIA P572.

作者信息

Diez-Echave Patricia, Martín-Cabrejas Izaskun, Garrido-Mesa José, Langa Susana, Vezza Teresa, Landete José M, Hidalgo-García Laura, Algieri Francesca, Mayer Melinda J, Narbad Arjan, García-Lafuente Ana, Medina Margarita, Rodríguez-Nogales Alba, Rodríguez-Cabezas María Elena, Gálvez Julio, Arqués Juan L

机构信息

Centro de Investigaciones Biomédicas en Red-Enfermedades Hepáticas y Digestivas (CIBER-EHD), Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Avenida del Conocimiento s/n, 18100 Granada, Spain.

Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, Spain.

出版信息

Nutrients. 2021 May 29;13(6):1860. doi: 10.3390/nu13061860.

DOI:10.3390/nu13061860
PMID:34072532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8228662/
Abstract

INIA P572 is a strain able to produce the antimicrobial compound reuterin in dairy products, exhibiting a protective effect against some food-borne pathogens. In this study, we investigated some probiotic properties of this strain such as resistance to gastrointestinal passage or to colonic conditions, reuterin production in a colonic environment, and immunomodulatory activity, using different in vitro and in vivo models. The results showed a high resistance of this strain to gastrointestinal conditions, as well as capacity to grow and produce reuterin in a human colonic model. Although the in vitro assays using the RAW 264.7 macrophage cell line did not demonstrate direct immunomodulatory properties, the in vivo assays using a Dextran Sulphate Sodium (DSS)-induced colitic mice model showed clear immunomodulatory and protective effects of this strain.

摘要

INIA P572是一种能够在乳制品中产生抗菌化合物罗伊氏菌素的菌株，对一些食源性病原体具有保护作用。在本研究中，我们使用不同的体外和体内模型，研究了该菌株的一些益生菌特性，如对胃肠道通过或结肠环境的抗性、在结肠环境中产生罗伊氏菌素的能力以及免疫调节活性。结果表明，该菌株对胃肠道条件具有高度抗性，并且在人结肠模型中具有生长和产生罗伊氏菌素的能力。尽管使用RAW 264.7巨噬细胞系的体外试验未显示出直接的免疫调节特性，但使用葡聚糖硫酸钠（DSS）诱导的结肠炎小鼠模型的体内试验显示该菌株具有明显的免疫调节和保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/339b8949f33a/nutrients-13-01860-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/dff7640bbc54/nutrients-13-01860-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/0b1bbfb585c9/nutrients-13-01860-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/cfc76e1e1c07/nutrients-13-01860-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/911223ced080/nutrients-13-01860-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/ff3651cc15d7/nutrients-13-01860-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/ca7b68879386/nutrients-13-01860-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/339b8949f33a/nutrients-13-01860-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/dff7640bbc54/nutrients-13-01860-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/0b1bbfb585c9/nutrients-13-01860-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/cfc76e1e1c07/nutrients-13-01860-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/911223ced080/nutrients-13-01860-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/ff3651cc15d7/nutrients-13-01860-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/ca7b68879386/nutrients-13-01860-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f7f/8228662/339b8949f33a/nutrients-13-01860-g007.jpg

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