Lev-Ari Shahar, Rolnik Benjamin, Volovitz Ilan
Tel-Aviv Sourasky Medical Center, Department of Health Promotion, School of Public Health, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
Healthcare Innovation Lab, Department of Genetics, Stanford Medicine, Stanford, CA 94305, USA.
Biology (Basel). 2021 May 29;10(6):485. doi: 10.3390/biology10060485.
The adaptive immune system was sculpted to protect individuals, societies, and species since its inception, developing effective strategies to cope with emerging pathogens. Here, we show that similar successful or failed dynamics govern personal and societal responses to a pathogen as SARS-CoV2. Understanding the self-similarity between the health-protective measures taken to protect the individual or the society, help identify critical factors underlying the effectiveness of societal response to a pathogenic challenge. These include (1) the quick employment of adaptive-like, pathogen-specific strategies to cope with the threat including the development of "memory-like responses"; (2) enabling productive coaction and interaction within the society by employing effective decision-making processes; and (3) the quick inhibition of positive feedback loops generated by hazardous or false information. Learning from adaptive anti-pathogen immune responses, policymakers and scientists could reduce the direct damages associated with COVID-19 and avert an avoidable "social cytokine storm" with its ensuing socioeconomic damage.
自适应性免疫系统形成以来，它就被塑造为保护个体、社会和物种，发展出应对新出现病原体的有效策略。在这里，我们表明，类似的成功或失败动态支配着个人和社会对如SARS-CoV2这样的病原体的反应。理解为保护个体或社会而采取的健康保护措施之间的自相似性，有助于确定社会应对致病挑战有效性背后的关键因素。这些因素包括：（1）迅速采用类似适应性的、针对病原体的策略来应对威胁，包括发展“类似记忆的反应”；（2）通过采用有效的决策过程，使社会内部能够进行富有成效的共同行动和互动；（3）迅速抑制由有害或虚假信息产生的正反馈回路。从适应性抗病原体免疫反应中学习，政策制定者和科学家可以减少与COVID-19相关的直接损害，并避免一场可避免的“社会细胞因子风暴”及其随之而来的社会经济损害。
