Department of Urology, Goethe-University, 60590 Frankfurt am Main, Germany.
Int J Mol Sci. 2021 May 31;22(11):5938. doi: 10.3390/ijms22115938.
Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs. This review summarizes current understanding regarding the influence of SFN on ROS and ROS-related pathways and appraises a possible role of SFN in bladder cancer treatment.
萝卜硫素（SFN）是十字花科蔬菜中发现的一种天然硫代葡萄糖苷，具有化学预防作用，但作用机制尚不清楚。由于抗氧化机制被认为是预防癌症进展的核心，SFN 可能在氧化过程中发挥作用。由于氧化还原失衡和活性氧（ROS）水平升高与膀胱癌的发生和发展有关，因此当发生化疗耐药时，这种机制可能与之相关。本综述总结了 SFN 对 ROS 和 ROS 相关途径影响的最新认识，并评价了 SFN 在膀胱癌治疗中的可能作用。
