Bernstein David L, Jiang Xinpei, Rom Slava
Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Biomedicines. 2021 May 26;9(6):606. doi: 10.3390/biomedicines9060606.
The family is among the first microRNAs found. Recent investigations have indicated that it is highly expressed in many systems, including cerebral and cardiovascular systems. Numerous studies have implicated the aberrant expression of members in cardiovascular diseases, such as stroke, myocardial infarction (MI), cardiac fibrosis, and atherosclerosis as well as in the inflammation related to these diseases. Furthermore, the microRNAs are involved in development and differentiation of embryonic stem cells in the cardiovascular system. Numerous genes have been identified as target genes of , as well as a number of the ' regulators. Further studies are necessary to identify the gene targets and signaling pathways of in cardiovascular diseases and inflammatory processes. The bulk of the ' regulatory proteins are well studied in development, proliferation, differentiation, and cancer, but their roles in inflammation, cardiovascular diseases, and/or stroke are not well understood. Further knowledge on the regulation of is crucial for therapeutic advances. This review focuses on research progress regarding the roles of and their regulation in cerebral and cardiovascular diseases and associated inflammation.
该家族是最早发现的微小RNA之一。最近的研究表明，它在包括脑和心血管系统在内的许多系统中高度表达。大量研究表明，其成员在心血管疾病（如中风、心肌梗死、心脏纤维化和动脉粥样硬化）以及与这些疾病相关的炎症中表达异常。此外，这些微小RNA参与心血管系统中胚胎干细胞的发育和分化。许多基因已被确定为该家族的靶基因，以及一些该家族的调节因子。有必要进一步研究以确定该家族在心血管疾病和炎症过程中的基因靶点和信号通路。该家族的大部分调节蛋白在发育、增殖、分化和癌症方面已得到充分研究，但其在炎症、心血管疾病和/或中风中的作用尚不清楚。进一步了解该家族的调节对于治疗进展至关重要。本综述重点关注该家族及其调节在脑和心血管疾病以及相关炎症中的作用的研究进展。
