Let-7 在心血管疾病、心脏发育和心血管分化中的作用。
Let-7 in cardiovascular diseases, heart development and cardiovascular differentiation from stem cells.
机构信息
Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
出版信息
Int J Mol Sci. 2013 Nov 21;14(11):23086-102. doi: 10.3390/ijms141123086.
The let-7 family is the second microRNA found in C. elegans. Recent researches have found it is highly expressed in the cardiovascular system. Studies have revealed the aberrant expression of let-7 members in cardiovascular diseases, such as heart hypertrophy, cardiac fibrosis, dilated cardiomyopathy (DCM), myocardial infarction (MI), arrhythmia, angiogenesis, atherosclerosis, and hypertension. Let-7 also participates in cardiovascular differentiation of embryonic stem cells. TLR4, LOX-1, Bcl-xl and AGO1 are by now the identified target genes of let-7. The circulating let-7b is suspected to be the biomarker of acute MI and let-7i, the biomarker of DCM. Further studies are necessary for identifying the gene targets and signaling pathways of let-7 in cardiovascular diseases. Let-7 might be a potential therapeutic target for cardiovascular diseases. This review focuses on the research progresses regarding the roles of let-7 in cardiovascular development and diseases.
Let-7 家族是在秀丽隐杆线虫中发现的第二个 microRNA。最近的研究发现，它在心血管系统中高度表达。研究表明，let-7 成员在心血管疾病中的表达异常，如心脏肥大、心脏纤维化、扩张型心肌病（DCM）、心肌梗死（MI）、心律失常、血管生成、动脉粥样硬化和高血压。Let-7 还参与胚胎干细胞的心血管分化。TLR4、LOX-1、Bcl-xl 和 AGO1 是目前已鉴定出的 let-7 靶基因。循环 let-7b 被怀疑是急性 MI 的生物标志物，let-7i 是 DCM 的生物标志物。进一步研究需要确定 let-7 在心血管疾病中的基因靶标和信号通路。Let-7 可能是心血管疾病的潜在治疗靶点。本综述重点介绍了 let-7 在心血管发育和疾病中的作用的研究进展。
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