Laboratory of Medical Genetics, Institute of Molecular Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia.
Laboratory of Epigenetics, Research Centre for Medical Genetics, 115522 Moscow, Russia.
Int J Mol Sci. 2021 May 26;22(11):5683. doi: 10.3390/ijms22115683.
Despite recent progress, gastric cancer remains one of the most common cancers and has a high mortality rate worldwide. Aberrant DNA methylation pattern and deregulation of noncoding RNA expression appear in the early stages of gastric cancer. Numerous investigations have confirmed their significant role in gastric cancer tumorigenesis and their high potential as diagnostic and prognostic biomarkers. Currently, it is clear that these epigenetic regulators do not work alone but interact with each other, generating a complex network. The aim of our review was to summarize the current knowledge of this interaction in gastric cancer and estimate its clinical potential for the diagnosis, prognosis, and treatment of the disease.
尽管最近取得了一些进展，但胃癌仍然是最常见的癌症之一，在全球范围内死亡率很高。异常的 DNA 甲基化模式和非编码 RNA 表达的失调出现在胃癌的早期阶段。大量的研究证实了它们在胃癌肿瘤发生中的重要作用，以及它们作为诊断和预后生物标志物的高潜力。目前，很明显，这些表观遗传调节剂不是单独起作用的，而是相互作用，形成一个复杂的网络。我们综述的目的是总结胃癌中这种相互作用的最新知识，并评估其在疾病的诊断、预后和治疗方面的临床潜力。
