外源性多胺对黄嘌呤氧化酶或刺激的多形核白细胞造成的溶酶体损伤的抗氧化作用。
Antioxidant effects of exogenous polyamines in damage of lysosomes inflicted by xanthine oxidase or stimulated polymorphonuclear leucocytes.
作者信息
Kafy A M, Lewis D A
机构信息
Pharmaceutical Sciences Institute, Aston University, Birmingham.
出版信息
Agents Actions. 1988 Jun;24(1-2):145-51. doi: 10.1007/BF01968093.
PMID:3407546
Abstract
Active oxygen species produced by the action of xanthine oxidase or stimulated guinea-pig polymorphonuclear leucocytes have a lytic action of lysosomes possibly due to lipid peroxidation. Polyamines give some protection against lysis with putrescine being the most effective polyamine. The possible relevance to inflammatory disease is discussed.
摘要
由黄嘌呤氧化酶作用或受刺激的豚鼠多形核白细胞产生的活性氧物质可能由于脂质过氧化作用而对溶酶体具有溶解作用。多胺可提供一定程度的抗溶解保护作用，其中腐胺是最有效的多胺。文中讨论了其与炎症性疾病的可能关联。
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