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外源性多胺对黄嘌呤氧化酶或刺激的多形核白细胞造成的溶酶体损伤的抗氧化作用。

Antioxidant effects of exogenous polyamines in damage of lysosomes inflicted by xanthine oxidase or stimulated polymorphonuclear leucocytes.

作者信息

Kafy A M, Lewis D A

机构信息

Pharmaceutical Sciences Institute, Aston University, Birmingham.

出版信息

Agents Actions. 1988 Jun;24(1-2):145-51. doi: 10.1007/BF01968093.

DOI:10.1007/BF01968093
PMID:3407546
Abstract

Active oxygen species produced by the action of xanthine oxidase or stimulated guinea-pig polymorphonuclear leucocytes have a lytic action of lysosomes possibly due to lipid peroxidation. Polyamines give some protection against lysis with putrescine being the most effective polyamine. The possible relevance to inflammatory disease is discussed.

摘要

由黄嘌呤氧化酶作用或受刺激的豚鼠多形核白细胞产生的活性氧物质可能由于脂质过氧化作用而对溶酶体具有溶解作用。多胺可提供一定程度的抗溶解保护作用,其中腐胺是最有效的多胺。文中讨论了其与炎症性疾病的可能关联。

相似文献

1
Antioxidant effects of exogenous polyamines in damage of lysosomes inflicted by xanthine oxidase or stimulated polymorphonuclear leucocytes.外源性多胺对黄嘌呤氧化酶或刺激的多形核白细胞造成的溶酶体损伤的抗氧化作用。
Agents Actions. 1988 Jun;24(1-2):145-51. doi: 10.1007/BF01968093.
2
In vitro interactions between endogenous polyamines and superoxide anion.
Agents Actions. 1986 Aug;18(5-6):555-9. doi: 10.1007/BF01964964.
3
[Studies on anti-inflammatory agents. XXIII. Membrane stabilizing action of tinoridine on lysosomes of polymorphonuclear leucocytes from guinea-pigs (author's transl)].[抗炎剂的研究。二十三。替诺立定对豚鼠多形核白细胞溶酶体的膜稳定作用(作者译)]
Yakugaku Zasshi. 1974 Jun;94(6):660-5. doi: 10.1248/yakushi1947.94.6_660.
4
Polyamines modify paraquat-induced changes in pulmonary superoxide dismutase and lipid peroxidation.多胺可改变百草枯诱导的肺超氧化物歧化酶及脂质过氧化的变化。
Res Commun Chem Pathol Pharmacol. 1982 Feb;35(2):337-40.
5
Peroxidation of linolenic acid promoted by human polymorphonuclear leucocytes.人多形核白细胞促进亚麻酸的过氧化反应。
J Free Radic Biol Med. 1985;1(4):255-61. doi: 10.1016/0748-5514(85)90129-1.
6
Acute and chronic effects of xanthine oxidase on lung thorax-compliance in guinea pigs.黄嘌呤氧化酶对豚鼠肺胸廓顺应性的急性和慢性影响。
Intensive Care Med. 1987;13(1):30-2. doi: 10.1007/BF00263554.
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Peroxidation of liposomes promoted by human polymorphonuclear leucocytes.人多形核白细胞促进脂质体的过氧化反应。
J Free Radic Biol Med. 1985;1(5-6):437-42. doi: 10.1016/0748-5514(85)90158-8.
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Evidence that peroxidation of lysosomal membranes is initiated by hydroxyl free radicals produced during flavin enzyme activity.有证据表明,溶酶体膜的过氧化作用是由黄素酶活性过程中产生的羟基自由基引发的。
J Biol Chem. 1973 Nov 25;248(22):7792-7.
9
Antioxidant defences in rat, pig, guinea pig, and human hearts: comparison with xanthine oxidoreductase activity.大鼠、猪、豚鼠和人类心脏中的抗氧化防御:与黄嘌呤氧化还原酶活性的比较。
Cardiovasc Res. 1993 Nov;27(11):2052-7. doi: 10.1093/cvr/27.11.2052.
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The effect of oxidant stress on diamide-treated human granulocytes.氧化应激对二酰胺处理的人粒细胞的影响。
Biochim Biophys Acta. 1979 Jul 18;585(4):620-9. doi: 10.1016/0304-4165(79)90194-6.

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Studies on the antiperoxide and antihaemolytic action of polyamines using human erythrocytes.利用人体红细胞对多胺的抗过氧化物和抗溶血作用的研究。
Indian J Clin Biochem. 2000 Aug;15(1):17-21. doi: 10.1007/BF02873542.
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Polyamines: Potential anti-inflammatory agents and their possible mechanism of action.多胺:潜在的抗炎剂及其可能的作用机制。
Indian J Pharmacol. 2008 Jun;40(3):121-5. doi: 10.4103/0253-7613.42305.
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Protective effect of spermine on DNA exposed to oxidative stress.精胺对暴露于氧化应激的DNA的保护作用。

本文引用的文献

1
BIOLOGICAL OXIDATIONS.生物氧化
Annu Rev Biochem. 1963;32:579-638. doi: 10.1146/annurev.bi.32.070163.003051.
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Free radicals and inflammation: superoxide-dependent activation of a neutrophil chemotactic factor in plasma.自由基与炎症:血浆中中性粒细胞趋化因子的超氧化物依赖性激活
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Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil particulate fractions, and an enzymatic generating system.乳铁蛋白可增强人中性粒细胞、中性粒细胞微粒部分以及一种酶促生成系统产生羟自由基的能力。
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Lipid peroxidation in rheumatoid arthritis: thiobarbituric acid-reactive material and catalytic iron salts in synovial fluid from rheumatoid patients.类风湿关节炎中的脂质过氧化:类风湿患者滑液中的硫代巴比妥酸反应性物质及催化性铁盐
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5
Putrescine--a potent endogenous anti-inflammatory substance in inflammatory exudates.腐胺——炎症渗出物中一种有效的内源性抗炎物质。
Agents Actions. 1983 Jun;13(4):342-7. doi: 10.1007/BF01971486.
6
Stabilization of erythrocyte membranes by polyamines.多胺对红细胞膜的稳定作用。
Proc Natl Acad Sci U S A. 1983 Apr;80(7):1942-6. doi: 10.1073/pnas.80.7.1942.
7
Polyamine binding to phospholipid vesicles and inhibition of lipid peroxidation.多胺与磷脂囊泡的结合及脂质过氧化的抑制
Biochem Biophys Res Commun. 1984 Jul 31;122(2):550-5. doi: 10.1016/s0006-291x(84)80068-6.
8
Superoxide radical: an endogenous toxicant.超氧阴离子自由基:一种内源性毒物。
Annu Rev Pharmacol Toxicol. 1983;23:239-57. doi: 10.1146/annurev.pa.23.040183.001323.
9
Production of superoxide, hydrogen peroxide and hydroxyl radicals by phagocytic cells: a cause of chronic inflammatory disease?吞噬细胞产生超氧化物、过氧化氢和羟基自由基:慢性炎症性疾病的一个病因?
Cell Biol Int Rep. 1982 Jun;6(6):529-42. doi: 10.1016/0309-1651(82)90175-8.
10
Oxygen metabolism and the toxic properties of phagocytes.氧代谢与吞噬细胞的毒性特性。
Ann Intern Med. 1980 Sep;93(3):480-9. doi: 10.7326/0003-4819-93-3-480.