UQ Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Royal Brisbane & Women's Hospital, Brisbane, QLD, Australia.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
J Neurosci Res. 2021 Sep;99(9):2097-2116. doi: 10.1002/jnr.24863. Epub 2021 Jun 2.
The present review asks whether magnetic resonance imaging (MRI) studies are able to define neural correlates of episodic memory within the hippocampus in Parkinson's disease (PD). Systematic searches were performed in PubMed, Web of Science, Medline, CINAHL, and EMBASE using search terms related to structural and functional MRI (fMRI), the hippocampus, episodic memory, and PD. Risk of bias was assessed for each study using the Newtown-Ottawa Scale. Thirty-nine studies met inclusion criteria; eight fMRI, seven diffusion MRI (dMRI), and 24 structural MRI (14 exploring whole hippocampus and 10 exploring hippocampal subfields). Critical analysis of the literature revealed mixed evidence from functional and dMRI, but stronger evidence from sMRI of the hippocampus as a biomarker for episodic memory impairment in PD. Hippocampal subfield studies most often implicated CA1, CA3/4, and subiculum volume in episodic memory and cognitive decline in PD. Despite differences in imaging methodology, study design, and sample characteristics, MRI studies have helped elucidate an important neural correlate of episodic memory impairment in PD with both clinical and theoretical implications. Natural progression of this work encourages future research on hippocampal subfield function as a potential biomarker of, or therapeutic target for, episodic memory dysfunction in PD.
本综述探讨了磁共振成像（MRI）研究是否能够在帕金森病（PD）患者的海马体中定义情景记忆的神经相关性。使用与结构和功能 MRI（fMRI）、海马体、情景记忆和 PD 相关的搜索词，在 PubMed、Web of Science、Medline、CINAHL 和 EMBASE 中进行了系统搜索。使用纽顿-渥太华量表（Newtown-Ottawa Scale）对每项研究的偏倚风险进行了评估。符合纳入标准的研究有 39 项；其中 8 项是 fMRI 研究，7 项是弥散张量成像（dMRI）研究，24 项是结构 MRI 研究（14 项研究整个海马体，10 项研究海马体亚区）。对文献的批判性分析显示，功能和 dMRI 的证据存在差异，但海马体 sMRI 的证据更强，表明其是 PD 患者情景记忆障碍的生物标志物。海马体亚区研究最常涉及 CA1、CA3/4 和下托体积与 PD 患者的情景记忆和认知能力下降有关。尽管成像方法、研究设计和样本特征存在差异，但 MRI 研究有助于阐明 PD 患者情景记忆障碍的重要神经相关性，具有临床和理论意义。这项工作的自然进展鼓励未来对海马体亚区功能作为 PD 患者情景记忆功能障碍的潜在生物标志物或治疗靶点的研究。
