Jurcau Anamaria, Nunkoo Vharoon Sharma
Neurology ward, Clinical Municipal Hospital "dr. G Curteanu" Oradea, Oradea, Romania.
Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Am J Alzheimers Dis Other Demen. 2021 Jan-Dec;36:15333175211021369. doi: 10.1177/15333175211021369.
The study aims at identifying features predictive of early onset of dementia in Parkinson's disease (PD).
103 non-demented PD patients were evaluated on various scales at baseline and 89 patients at 3-year follow-up.
By the end of the study 43.8% of patients developed dementia. The development of dementia was linked to the baseline Mini Mental State Examination score (Pearson coefficient r = .404, p = 0.013), the presence of autonomic dysfunctions (r = -.621, p < 0.001) and insomnia (r = -.526, p = 0.001). A binary logistic regression analysis showed that the development of dementia was correlated strongly with the presence of autonomic dysfunctions (95% CI 2.60 to 52.83, p < 0.001), and insomnia (95% CI 0.60 to 0.95, p = 0.017).
Patients with signs of autonomic dysfunction and insomnia are at higher risk for developing dementia and deserve closer monitoring of cognitive symptoms.
本研究旨在确定帕金森病（PD）中痴呆早期发作的预测特征。
103名非痴呆型PD患者在基线时接受了各种量表评估，89名患者在3年随访时接受评估。
研究结束时，43.8%的患者出现痴呆。痴呆的发生与基线简易精神状态检查表评分（皮尔逊系数r = 0.404，p = 0.013）、自主神经功能障碍的存在（r = -0.621，p < 0.001）和失眠（r = -0.526，p = 0.001）有关。二元逻辑回归分析表明，痴呆的发生与自主神经功能障碍的存在（95%置信区间2.60至52.83，p < 0.001）和失眠（95%置信区间0.60至0.95，p = 0.017）密切相关。
有自主神经功能障碍和失眠迹象的患者患痴呆的风险更高，值得对认知症状进行更密切的监测。
