领导肽交换产生杂交，新到自然核糖体天然产物。
Leader peptide exchange to produce hybrid, new-to-nature ribosomal natural products.
机构信息
Workgroup Structural Biology of Biosynthetic Enzymes, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, Campus Geb. E8.1, Saarbrücken 66123, Germany.
Workgroup Structural Biology of Biosynthetic Enzymes, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University, Campus Geb. E8.1, Saarbrücken 66123, Germany and School of Chemistry, University of Glasgow, Glasgow, UK.
出版信息
Chem Commun (Camb). 2021 Jun 29;57(52):6372-6375. doi: 10.1039/d0cc06889f.
Ribosomal natural products contain exquisite post-translational peptide modifications that are installed by a range of pathway-specific enzymes. We present proof of principle for a Sortase A-based approach that enables peptide modification by enzymes from unrelated pathways. This allowed the one-pot synthesis of a new-to-nature, hybrid ribosomal natural product.
核糖体天然产物含有精致的翻译后肽修饰，这些修饰是由一系列特定途径的酶来安装的。我们提出了一种基于 Sortase A 的方法的原理验证，该方法能够使来自不同途径的酶进行肽修饰。这使得一种新型的混合核糖体天然产物可以一锅合成。
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