National Central Cancer Registry, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cancer Med. 2021 Jul;10(13):4575-4586. doi: 10.1002/cam4.4014. Epub 2021 Jun 2.
Cancer is a major concern for children and adolescents worldwide. This study aims to report on cancer incidence patterns at age 0-19 years in 2011-2015 and their trends in 2000-2015.
We collected data on malignancies in population of 0-19 years submitted by high-quality population-based cancer registries in China. Age-standardized rates by world standard population (WSR) and annual percent change (APC) were calculated.
In total, 215 cancer registries from 30 provinces contributed datasets during 2011-2015. Twenty-two registries provided continuous data for trend analysis from 2000 to 2015. In total 16,954 malignancies occurred in 177,416,582 person-years. WSRs were 93.32 and 96.03 per million person-years in children aged 0-14 and 0-19 years. Incidence rates were higher in boys than in girls and were higher in urban area than in rural area. In children aged 0-14 years, the top three common diagnostic groups were leukemia, central nervous system (CNS) tumors, and lymphomas in both sexes. In adolescents aged 15-19 years, the top three common diagnostic groups were leukemia, epithelial tumors and melanoma, and CNS tumors in boys and epithelial tumors and melanoma, leukemia, and germ cell and gonadal tumors in girls. WSRs for cancers in 0-19 years of age increased significantly in boys from 2000 to 2005 (APC = 5.3%, 95% CI: 2.3%-8.3%) and in girls from 2000 to 2015 (APC = 1.2%, 95% CI: 0.1%-2.4%).
Cancer incidence in children and adolescents is on the rise in China. The observed age, sex, and geographical variations in cancer incidence should be used to inform targeted prevention and control policies.
癌症是全世界儿童和青少年的主要关注点。本研究旨在报告 2011-2015 年 0-19 岁人群癌症发病模式及其 2000-2015 年的趋势。
我们收集了中国高质量基于人群的癌症登记处提交的 0-19 岁人群恶性肿瘤数据。按世界标准人口（WSR）计算年龄标准化率和年变化百分比（APC）。
共有来自 30 个省的 215 个癌症登记处于 2011-2015 年期间提供了数据集。22 个登记处提供了 2000-2015 年的连续数据进行趋势分析。共发生 16954 例恶性肿瘤，177416582 人年。0-14 岁和 0-19 岁儿童的 WSR 分别为 93.32 和 96.03/百万人口年。发病率在男孩中高于女孩，在城市地区高于农村地区。在 0-14 岁儿童中，男女最常见的诊断组别均为白血病、中枢神经系统（CNS）肿瘤和淋巴瘤。在 15-19 岁青少年中，男孩最常见的诊断组别为白血病、上皮肿瘤和黑色素瘤、CNS 肿瘤，女孩最常见的诊断组别为上皮肿瘤和黑色素瘤、白血病、生殖细胞和性腺肿瘤。2000-2005 年男孩（APC=5.3%，95%CI：2.3%-8.3%）和 2000-2015 年女孩（APC=1.2%，95%CI：0.1%-2.4%）0-19 岁年龄组癌症的 WSR 显著上升。
中国儿童和青少年癌症发病率呈上升趋势。观察到的癌症发病率在年龄、性别和地理方面的差异，应用于制定有针对性的预防和控制政策。
