Zhang Dan-Feng, Jiang Guang-Bin, Qin Chuan-Qi, Liu De-Xi, Hu Ya-Jun, Zhou Juan, Niu Yu-Ming
Center for Evidence-Based Medicine and Clinical Research, Department of Endocrine Vascular Surgery, Taihe Hospital, Shiyan Department of Radiology, Suizhou Central Hospital, Suizhou The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine, Ministry of Education, Department of Oral and Maxillofacial Surgery, School & Hospital of Stomatology, Wuhan University, Wuhan Center for Evidence-Based Medicine and Clinical Research, Department of Stomatology, Taihe Hospital, Shiyan, China.
Medicine (Baltimore). 2018 Feb;97(6):e9873. doi: 10.1097/MD.0000000000009873.
Molecular epidemiological studies have demonstrated a closer association between Fas/FasL polymorphisms and head and neck cancer (HNC) risk, and the results of these published studies were inconsistent. We therefore performed this meta-analysis to explore the associations between Fas/FasL polymorphisms and HNC risk.
Four online databases (PubMed, Embase, CNKI, and Wanfang) were searched. Odds ratios (ORs) with 95% confidence interval (95% CIs) were calculated to assess the association between Fas -670A>G, Fas -1377G>A, and FasL -844C>T polymorphisms and HNC risk. In addition, heterogeneity, accumulative/sensitivity analysis, and publication bias were conducted to check the statistical power.
Overall, 9 related publications (20 independent case-control studies) involving 3179 patients and 4217 controls were identified. Significant association of protective effects was observed between FasL -844C>T polymorphism and HNC risk in codominant and dominant model models (CT vs CC: OR = 0.89, 95% CI = 0.79-1.00, P = .05, I = 38.3%, CT+TT vs CC: OR = 0.88, 95% CI = 0.79-0.98, P = .02, I = 35.8%). Furthermore, the similar protective effects were observed the subgroup analysis of in Asian population and population-based controls group.
Our meta-analysis indicated that FasL -844C>T polymorphism plays a protective role against HNC development, but the Fas -670A>G and Fas -1377G>A polymorphisms maybe not associated with HNC risk.
分子流行病学研究表明，Fas/FasL基因多态性与头颈癌（HNC）风险之间存在更密切的关联，而这些已发表研究的结果并不一致。因此，我们进行了这项荟萃分析，以探讨Fas/FasL基因多态性与HNC风险之间的关联。
检索了四个在线数据库（PubMed、Embase、CNKI和万方）。计算比值比（OR）及95%置信区间（95%CI），以评估Fas -670A>G、Fas -1377G>A和FasL -844C>T基因多态性与HNC风险之间的关联。此外，进行了异质性、累积/敏感性分析和发表偏倚分析，以检验统计效能。
共纳入9篇相关文献（20项独立的病例对照研究），涉及3179例患者和4217例对照。在共显性和显性模型中，观察到FasL -844C>T基因多态性与HNC风险之间存在显著的保护作用关联（CT与CC比较：OR = 0.89，95%CI = 0.79 - 1.00，P = 0.05，I² = 38.3%；CT + TT与CC比较：OR = 0.88，95%CI = 0.79 - 0.98，P = 0.02，I² = 35.8%）。此外，在亚洲人群和基于人群的对照组的亚组分析中也观察到了类似的保护作用。
我们的荟萃分析表明，FasL -844C>T基因多态性对HNC的发生具有保护作用，但Fas -670A>G和Fas -1377G>A基因多态性可能与HNC风险无关。
