Pavlov A V, Antipanova E M, Zapriagaev V V
Arkh Anat Gistol Embriol. 1988 Apr;94(4):40-3.
By means of morphological, morphometrical and autoradiographical methods restorative processes in the parathyroid glands in 41 euthyroid and in 41 hypothyroid rats have been studied during 1-24 days after mechanical trauma of the glands or after hemithyroparathyroidectomy. Seven hypothyroid and 7 euthyroid rats serve as a control. Hypothyroidism is produced with daily injection of mercazolil (6 mg/kg) 3 weeks before the operation and during the time of the experiment. In nonoperated hypothyroid rats development of hypertrophy in parathyrocytes is noted. Prolonged injection of mercazolil weakens (posttraumatic regeneration) or completely suppresses (compensatory hypertrophy) mitotic activity of the glandular cells (in comparison with the euthyroid animals). Manifestation of hypertrophy in parathyrocytes of the hypothyroid rats in comparison with the corresponding control is also less, than against the background of euthyreosis.
通过形态学、形态计量学和放射自显影方法，对41只甲状腺功能正常和41只甲状腺功能减退大鼠在甲状旁腺受到机械创伤或半甲状腺甲状旁腺切除术后1至24天内的甲状旁腺修复过程进行了研究。7只甲状腺功能减退和7只甲状腺功能正常的大鼠作为对照。甲状腺功能减退是在手术前3周及实验期间每天注射甲巯咪唑（6mg/kg）产生的。在未手术的甲状腺功能减退大鼠中，观察到甲状旁细胞肥大的发展。与甲状腺功能正常的动物相比，长期注射甲巯咪唑会削弱（创伤后再生）或完全抑制（代偿性肥大）腺细胞的有丝分裂活性。与相应对照相比，甲状腺功能减退大鼠甲状旁细胞肥大的表现也比甲状腺功能正常时少。
