Minaiyan Mohsen, Sadraei Hassan, Yousefi Iman, Sajjadi Sayed-Ebrahim, Talebi Ardeshir
Department of Pharmacology and Toxicology and Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Res Pharm Sci. 2021 Mar 5;16(2):141-152. doi: 10.4103/1735-5362.310521. eCollection 2021 Apr.
() is a fragrant wild medicinal plant found in Iran. Traditionally, it is used for the treatment of rheumatism, asthma, and gastrointestinal ailments. So far no investigation has been done on the beneficial or side effects of on peptic ulcer. Therefore, this research was performed to find out whether extract would induce peptic ulcer or could alleviate existing peptic ulcer.
Effect of hydroalcoholic (DKHE) and flavonoid extracts (DKFE) of were determined in normal or indomethacin-induced gastric ulcer rats (n = 6) and compared with the vehicle and ranitidine treated controls. All the treatments were carried out orally and 24 h later the stomach mucus was visually examined for peptic ulcers. A section of the stomach was taken for microscopic histopathological examinations while another section of the stomach was used for measurement of myeloperoxidase (MPO) and malondialdehyde (MDA) activities.
FINDINGS/RESULTS: Oral administration of the DKHE and DKFE alone, did not cause any sign of gastric ulcer induction. The extracts not only didn't aggravate the induced ulcer but also significantly prevented the severity of gastric ulcer induction by indomethacin. In addition, DKHE and DKFE inhibited MPO (up to 58.2%) and MDA (up to 44.2%) activities indicating their anti-inflammatory and antioxidant potential action on the stomach-induced ulcer.
Usage of extracts is not associated with gastric ulcer induction and its co-administration with NSAIDs would be beneficial for controlling both the inflammation and preventing gastric ulcer in diseases such as rheumatism.
（）是一种在伊朗发现的芳香野生药用植物。传统上，它用于治疗风湿病、哮喘和胃肠道疾病。迄今为止，尚未对其对消化性溃疡的有益或副作用进行研究。因此，本研究旨在确定（）提取物是否会诱发消化性溃疡或能否缓解现有的消化性溃疡。
在正常或吲哚美辛诱导的胃溃疡大鼠（n = 6）中测定（）的水醇提取物（DKHE）和黄酮类提取物（DKFE）的作用，并与载体和雷尼替丁治疗的对照组进行比较。所有处理均经口服进行，24小时后肉眼检查胃黏液是否有消化性溃疡。取一部分胃组织进行显微镜组织病理学检查，另一部分胃组织用于测定髓过氧化物酶（MPO）和丙二醛（MDA）活性。
单独口服DKHE和DKFE未引起任何胃溃疡诱导迹象。（）提取物不仅没有加重诱导的溃疡，而且显著预防了吲哚美辛诱导的胃溃疡的严重程度。此外，DKHE和DKFE抑制MPO（高达58.2%）和MDA（高达44.2%）活性，表明它们对胃诱导溃疡具有抗炎和抗氧化潜在作用。
（）提取物的使用与胃溃疡诱导无关，其与非甾体抗炎药联合使用将有利于控制炎症和预防风湿病等疾病中的胃溃疡。
