Emotion & Development Branch, National Institute of Mental Health, Bethesda, MD, United States of America.
Department of Electrical and Biomedical Engineering, University of Vermont, Burlington, VT, United States of America.
PLoS One. 2021 Jun 4;16(6):e0252245. doi: 10.1371/journal.pone.0252245. eCollection 2021.
Identification of behavioral mechanisms underlying psychopathology is essential for the development of novel targeted therapeutics. However, this work relies on rigorous, time-intensive, clinic-based laboratory research, making it difficult to translate research paradigms into tools that can be used by clinicians in the community. The broad adoption of smartphone technology provides a promising opportunity to bridge the gap between the mechanisms identified in the laboratory and the clinical interventions targeting them in the community. The goal of the current study is to develop a developmentally appropriate, engaging, novel mobile application called CALM-IT that probes a narrow biologically informed process, inhibitory control. We aim to leverage the rigorous and robust methods traditionally used in laboratory settings to validate this novel mechanism-driven but easily disseminatable tool that can be used by clinicians to probe inhibitory control in the community. The development of CALM-IT has significant implications for the ability to screen for inhibitory control deficits in the community by both clinicians and researchers. By facilitating assessment of inhibitory control outside of the laboratory setting, researchers could have access to larger and more diverse samples. Additionally, in the clinical setting, CALM-IT represents a novel clinical screening measure that could be used to determine personalized courses of treatment based on the presence of inhibitory control deficits.
确定精神病理学的行为机制对于开发新型靶向治疗方法至关重要。然而，这项工作依赖于严格、耗时的临床实验室研究，使得很难将研究范式转化为社区临床医生可以使用的工具。智能手机技术的广泛采用为弥合实验室中确定的机制与针对社区中这些机制的临床干预之间的差距提供了一个有前途的机会。本研究的目的是开发一种名为 CALM-IT 的适合发展、引人入胜的新型移动应用程序，该应用程序可以探测到一种狭隘的生物学上有依据的过程，即抑制控制。我们旨在利用传统上在实验室环境中使用的严格而强大的方法来验证这种新型的机制驱动但易于传播的工具，临床医生可以使用该工具来探测社区中的抑制控制。CALM-IT 的开发对于临床医生和研究人员在社区中筛选抑制控制缺陷的能力具有重要意义。通过促进实验室环境之外的抑制控制评估，研究人员可以获得更大和更多样化的样本。此外，在临床环境中，CALM-IT 代表了一种新型的临床筛选措施，可用于根据抑制控制缺陷的存在确定个性化的治疗方案。
