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注意偏向修正训练作为酒精和大麻使用障碍常规治疗的附加手段的疗效:一项多中心随机对照试验。

Effectiveness of attentional bias modification training as add-on to regular treatment in alcohol and cannabis use disorder: A multicenter randomized control trial.

机构信息

Verslavingszorg Noord Nederland, Groningen, The Netherlands.

Department of Clinical Psychology and Experimental Psychopathology, University of Groningen, Groningen, The Netherlands.

出版信息

PLoS One. 2021 Jun 4;16(6):e0252494. doi: 10.1371/journal.pone.0252494. eCollection 2021.

Abstract

BACKGROUND

Attentional bias for substance-relevant cues has been found to contribute to the persistence of addiction. Attentional bias modification (ABM) interventions might, therefore, increase positive treatment outcome and reduce relapse rates. The current study investigated the effectiveness of a newly developed home-delivered, multi-session, internet-based ABM intervention, the Bouncing Image Training Task (BITT), as an add-on to treatment as usual (TAU).

METHODS

Participants (N = 169), diagnosed with alcohol or cannabis use disorder, were randomly assigned to one of two conditions: the experimental ABM group (50%; TAU+ABM); or the control group (50%; split in two subgroups the TAU+placebo group and TAU-only group, 25% each). Participants completed baseline, post-test, and 6 and 12 months follow-up measures of substance use and craving allowing to assess long-term treatment success and relapse rates. In addition, attentional bias (both engagement and disengagement), as well as secondary physical and psychological complaints (depression, anxiety, and stress) were assessed.

RESULTS

No significant differences were found between conditions with regard to substance use, craving, relapse rates, attentional bias, or physical and psychological complaints.

CONCLUSIONS

The findings may reflect unsuccessful modification of attentional bias, the BITT not targeting the relevant process (engagement vs. disengagement bias), or may relate to the diverse treatment goals of the current sample (i.e., moderation or abstinence). The current findings provide no support for the efficacy of this ABM approach as an add-on to TAU in alcohol or cannabis use disorder. Future studies need to delineate the role of engagement and disengagement bias in the persistence of addiction, and the role of treatment goal in the effectiveness of ABM interventions.

摘要

背景

对物质相关线索的注意力偏向被认为有助于成瘾的持续。因此,注意力偏向修正(ABM)干预可能会增加积极的治疗效果并降低复发率。本研究调查了一种新开发的家庭式、多疗程、基于互联网的 ABM 干预措施,即反弹图像训练任务(BITT),作为治疗的附加手段的效果。

方法

参与者(N=169)被诊断为酒精或大麻使用障碍,随机分配到两个条件之一:实验组(ABM;50%;TAU+ABM);或对照组(50%;分为两个亚组,即 TAU+安慰剂组和 TAU 仅组,各占 25%)。参与者完成了基线、后测以及 6 个月和 12 个月的随访,以评估物质使用和渴求情况,从而评估长期治疗效果和复发率。此外,还评估了注意力偏向(包括投入和脱离)以及二级身体和心理问题(抑郁、焦虑和压力)。

结果

在物质使用、渴求、复发率、注意力偏向或身体和心理问题方面,两个条件之间没有发现显著差异。

结论

这些发现可能反映了注意力偏向修正不成功,BITT 未针对相关过程(投入与脱离偏向),或者可能与当前样本的不同治疗目标有关(即适度或戒断)。目前的研究结果不支持将这种 ABM 方法作为酒精或大麻使用障碍治疗的附加手段的疗效。未来的研究需要阐明投入和脱离偏向在成瘾持续中的作用,以及治疗目标在 ABM 干预效果中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0992/8177423/5012b441db2f/pone.0252494.g001.jpg

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