基于互联网的注意力偏差矫正训练作为酒精和大麻依赖门诊患者常规治疗的补充：一项随机对照试验的研究方案
Internet-based attentional bias modification training as add-on to regular treatment in alcohol and cannabis dependent outpatients: a study protocol of a randomized control trial.
作者信息
Heitmann Janika, van Hemel-Ruiter Madelon E, Vermeulen Karin M, Ostafin Brian D, MacLeod Colin, Wiers Reinout W, DeFuentes-Merillas Laura, Fledderus Martine, Markus Wiebren, de Jong Peter J
机构信息
Verslavingszorg Noord Nederland, Leonard Springerlaan 27, 9727 KB, Groningen, The Netherlands.
Experimental and Clinical Psychology, Department of Psychology, University of Groningen, Grote Kruisstraat 2/1, 9712 TS, Groningen, The Netherlands.
出版信息
BMC Psychiatry. 2017 May 23;17(1):193. doi: 10.1186/s12888-017-1359-2.
BACKGROUND
The automatic tendency to attend to and focus on substance-related cues in the environment (attentional bias), has been found to contribute to the persistence of addiction. Attentional bias modification (ABM) interventions might, therefore, contribute to treatment outcome and the reduction of relapse rates. Based on some promising research findings, we designed a study to test the clinical relevance of ABM as an add-on component of regular intervention for alcohol and cannabis patients.
DESIGN/METHODS: The current protocol describes a study which will investigate the effectiveness and cost-effectiveness of a newly developed home-delivered, multi-session, internet-based ABM (iABM) intervention as an add-on to treatment as usual (TAU). TAU consists of cognitive behavioural therapy-based treatment according to the Dutch guidelines for the treatment of addiction. Participants (N = 213) will be outpatients from specialized addiction care institutions diagnosed with alcohol or cannabis dependency who will be randomly assigned to one of three conditions: TAU + iABM; TAU + placebo condition; TAU-only. Primary outcome measures are substance use, craving, and rates of relapse. Changes in attentional bias will be measured to investigate whether changes in primary outcome measures can be attributed to the modification of attentional bias. Indices of cost-effectiveness and secondary physical and psychological complaints (depression, anxiety, and stress) are assessed as secondary outcome measures.
DISCUSSION
This randomized control trial will be the first to investigate whether a home-delivered, multi-session iABM intervention is (cost-) effective in reducing relapse rates in alcohol and cannabis dependency as an add-on to TAU, compared with an active and a waiting list control group. If proven effective, this ABM intervention could be easily implemented as a home-delivered component of current TAU.
TRIAL REGISTRATION
Netherlands Trial Register, NTR5497 , registered on 18th September 2015.
背景
人们发现，自动关注并聚焦于环境中与物质相关线索的倾向（注意力偏差）会导致成瘾行为持续存在。因此，注意力偏差修正（ABM）干预措施可能有助于改善治疗效果并降低复发率。基于一些有前景的研究结果，我们设计了一项研究，以测试ABM作为酒精和大麻成瘾患者常规干预附加组成部分的临床相关性。
设计/方法：本方案描述了一项研究，该研究将调查一种新开发的、通过互联网在家中进行的多疗程ABM（iABM）干预措施作为常规治疗（TAU）附加治疗的有效性和成本效益。TAU包括根据荷兰成瘾治疗指南进行的基于认知行为疗法的治疗。参与者（N = 213）将是来自专门成瘾护理机构的门诊患者，被诊断为酒精或大麻依赖，他们将被随机分配到以下三种情况之一：TAU + iABM；TAU + 安慰剂组；仅TAU。主要结局指标是物质使用、渴望和复发率。将测量注意力偏差的变化，以调查主要结局指标的变化是否可归因于注意力偏差的修正。成本效益指标以及次要的身体和心理不适（抑郁、焦虑和压力）作为次要结局指标进行评估。
讨论
这项随机对照试验将首次调查与积极对照组和等待名单对照组相比，一种通过互联网在家中进行的多疗程iABM干预措施作为TAU附加治疗在降低酒精和大麻依赖复发率方面是否（具有成本）有效。如果被证明有效，这种ABM干预措施可以很容易地作为当前TAU在家中进行的组成部分实施。
试验注册
荷兰试验注册库，NTR5497，于2015年9月18日注册。
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