Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University Hospitals, Assiut, Egypt.
Dermatol Ther. 2021 Jul;34(4):e15025. doi: 10.1111/dth.15025. Epub 2021 Jun 11.
Melasma is a disfiguring dermatologic condition and its treatment is still considered a challenge. To evaluate the efficacy and safety of microdermabrasion (MDA) combined with glycolic acid 70% (GA70%) peel versus GA70% alone in treating melasma in dark-skinned patients. This study included 30 female patients (skin type IV and V) with melasma. After cleansing the face, 3 passes of MDA were done on one side of the face. Then, GA70% was applied to the whole face in 1-2 uniform passes. Melasma area and severity index (MASI), modified MASI and hemi-MASI scores were used to assess the outcome. A significant decline of the mean MASI, mMASI and both hemi-MASI scores following treatment (p value = 0.000 for each). Furthermore, the hemi-MASI score on the MDA/GA70% treated side showed significantly greater decrease than the hemi-MASI score on GA70% treated side (p value = 0.041). MDA enhanced the improvement of GA70% peel effectively and safely.
黄褐斑是一种影响容貌的皮肤疾病，其治疗仍然是一个挑战。本研究旨在评估微磨削术（MDA）联合 70%甘醇酸（GA70%）换肤术与单独 GA70%换肤术治疗深色皮肤患者黄褐斑的疗效和安全性。该研究纳入了 30 名黄褐斑女性患者（皮肤类型为 IV 型和 V 型）。洁面后，在一侧面部进行 3 次 MDA 治疗。然后，将 GA70%均匀涂抹于整个面部 1-2 次。采用黄褐斑面积和严重程度指数（MASI）、改良 MASI 和半面 MASI 评分评估疗效。治疗后，平均 MASI、mMASI 和双侧半面 MASI 评分均显著下降（p 值分别为 0.000）。此外，MDA/GA70%治疗侧的半面 MASI 评分下降幅度明显大于 GA70%治疗侧（p 值为 0.041）。MDA 可有效增强 GA70%换肤术的疗效。
