Isfahan Eye Research Center, Department of Ophthalmology, Isfahan University of Medical Sciences, Isfahan, Iran.
Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
BMC Ophthalmol. 2021 Jun 5;21(1):251. doi: 10.1186/s12886-021-02008-z.
To present the very rare comorbidity of developing non-specific orbital inflammation (NSOI) in two patients with histories of definite thyroid eye disease (TED).
Both patients complained of new-onset progressive proptosis although their thyroid disease was controlled and computed tomography scan revealed an intraorbital inflammatory mass. The pathological assessment indicated that both patients had developed fibrosing NSOI. Therefore, intravenous corticosteroids were administered. The mass regressed and the amount of proptosis was decreased in both patients.
We reviewed all related cases in the literature and extracted their clinical and radiological characteristics for this paper. Ophthalmologists should consider TED and NSOI in patients with a new-onset complaint of proptosis. Despite rare comorbidity of TED and NSOI, it should be considered especially in patients with refractory proptosis, and lead to its further evaluation and prompt management.
介绍两例有明确甲状腺眼病（TED）病史的患者中出现非特异性眼眶炎症（NSOI）的极罕见合并症。
两名患者均主诉新出现进行性眼球突出，尽管甲状腺疾病得到控制，且计算机断层扫描显示眶内炎症性肿块。病理评估表明两名患者均发生纤维性 NSOI。因此给予静脉内皮质类固醇治疗。肿块消退，两名患者的眼球突出度均减少。
我们复习了文献中所有相关病例，并提取了其临床和影像学特征。眼科医生应考虑 TED 和 NSOI 患者出现新的眼球突出主诉。尽管 TED 和 NSOI 的合并症罕见，但应特别考虑到难治性眼球突出患者，这可能导致进一步评估和及时治疗。
