Centre for Healthy Ageing and Wellness (HCARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Geriatric Division, Faculty of Medicine, University Malaya Medical Center, Kuala Lumpur, Malaysia.
J Alzheimers Dis. 2021;82(2):673-687. doi: 10.3233/JAD-201607.
Cognitive frailty (CF) is identified as one of the main precursors of dementia. Multidomain intervention has been found to delay or prevent the onset of CF.
The aim of our present study is to determine the effectiveness of a comprehensive, multidomain intervention on CF; to evaluate its cost effectiveness and the factors influencing adherence toward this intensive intervention.
A total of 1,000 community dwelling older adults, aged 60 years and above will be screened for CF. This randomized controlled trial involves recruitment of 330 older adults with CF from urban, semi-urban, and rural areas in Malaysia. Multidomain intervention comprised of physical, nutritional, cognitive, and psychosocial aspects will be provided to participants in the experimental group (n = 165). The control group (n = 165) will continue their usual care with their physician. Primary outcomes include CF status, physical function, psychosocial and nutritional status as well as cognitive performance. Vascular health and gut microbiome will be assessed using blood and stool samples. A 24-month intensive intervention will be prescribed to the participants and its sustainability will be assessed for the following 12 months. The effective intervention strategies will be integrated as a personalized telerehabilitation package for the reversal of CF for future use.
The multidomain intervention developed from this trial is expected to be cost effective compared to usual care as well as able is to reverse CF.
This project will be part of the World-Wide FINGERS (Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability) Network, of which common identifiable data will be shared and harmonized among the consortia.
认知脆弱（CF）被认为是痴呆症的主要前兆之一。多领域干预已被发现可延迟或预防 CF 的发生。
本研究旨在确定综合多领域干预对 CF 的有效性；评估其成本效益以及影响对这种强化干预的依从性的因素。
将对 1000 名居住在社区的 60 岁及以上老年人进行 CF 筛查。这是一项随机对照试验，涉及从马来西亚城市、半城市和农村地区招募 330 名患有 CF 的老年人。实验组（n=165）将接受身体、营养、认知和心理社会方面的多领域干预。对照组（n=165）将继续接受他们的常规医疗护理。主要结局包括 CF 状态、身体功能、心理社会和营养状况以及认知表现。将使用血液和粪便样本评估血管健康和肠道微生物组。将为参与者开出为期 24 个月的强化干预，并在接下来的 12 个月内评估其可持续性。有效的干预策略将整合为一个个性化的远程康复方案，用于逆转 CF，以备将来使用。
与常规护理相比，预计从这项试验中开发的多领域干预措施具有成本效益，并且能够逆转 CF。
该项目将成为世界范围内 FINGERS（芬兰老年干预研究以预防认知障碍和残疾）网络的一部分，其中将共享和协调联盟之间的共同可识别数据。
