Lin Siyang, Wang Fang, Huang Min, Chen Jingyi, Jiang Xinye, Li Qiaowei, Yuan Yin, Huang Feng, Zhu Pengli
Fuzhou University Affiliated Provincial Hospital, Fuzhou, China.
Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Ann Med. 2025 Dec;57(1):2496409. doi: 10.1080/07853890.2025.2496409. Epub 2025 Apr 29.
The exploration of interventions to delay aging is an emerging topic that promotes healthy aging. The multidomain intervention has the potential to be applied in the field of aging because it concentrates on the functional ability of older adults. There is currently no literature reporting on a multidomain intervention involving cognition, exercise and nutrition for delaying aging.
The Multidomain Intervention for Delaying Aging in Community-dwelling Older Adults (MIDA) is a Zelen-design randomized controlled trial with a 6-month intervention duration. The multidomain intervention comprises cognitive training, exercise training, and nutritional guidance, delivered through both group sessions and individual family interventions. A total of 248 participants aged 60 to 85 years will be randomized to the intervention group or control group and followed up for 12 months. The primary outcome is the change in epigenetic age acceleration and pace of aging following the multidomain intervention. The secondary outcomes are the changes in frailty score and intrinsic capacity Z-score. Other outcomes include physical functions, body composition, aging biomarkers, inflammatory markers, haematology and biochemistry parameters, and lifestyle factors.
This study will explore the effects of the multidomain intervention on delaying aging in community-dwelling older adults. We aim to introduce a new approach to delaying aging and offer a practical multidomain intervention strategy for healthcare institutions.
探索延缓衰老的干预措施是一个促进健康老龄化的新兴话题。多领域干预有可能应用于老龄化领域，因为它关注老年人的功能能力。目前尚无关于涉及认知、运动和营养的多领域干预延缓衰老的文献报道。
社区居住老年人延缓衰老多领域干预（MIDA）是一项采用泽伦设计的随机对照试验，干预持续时间为6个月。多领域干预包括认知训练、运动训练和营养指导，通过小组课程和个别家庭干预进行。共有248名年龄在60至85岁之间的参与者将被随机分配到干预组或对照组，并随访12个月。主要结局是多领域干预后表观遗传年龄加速和衰老速度的变化。次要结局是衰弱评分和内在能力Z评分的变化。其他结局包括身体功能、身体成分、衰老生物标志物、炎症标志物、血液学和生物化学参数以及生活方式因素。
本研究将探索多领域干预对社区居住老年人延缓衰老的影响。我们旨在引入一种延缓衰老 的新方法，并为医疗机构提供一种实用的多领域干预策略。
