Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.
Department of Industrial Engineering, University of Rome "Tor Vergata", 00133 Rome, Italy.
Biomed Res Int. 2021 May 13;2021:4948139. doi: 10.1155/2021/4948139. eCollection 2021.
Dentoalveolar surgery is probably the major risk factor for MRONJ and for other complications following a tooth extraction, especially in patients affected by systemic diseases. The aim of this retrospective study is to evaluate whether a PRF plug inserted in the post extraction socket can prevent the onset of MRONJ. The patients were divided into two groups according to the surgical protocol that included the insertion or not of the PRF following the extraction and all the anamnestic, and clinical data were analyzed. In the control group, 5 patients developed MRONJ (19.23%) while in the study group, any case of MRONJ was reported. In the control group, patients who developed MRONJ had a CTX with less than 100 pg/mL (5 high-risk patients, Spearman's rank = .547, < .001). The use of platelet concentrates in patients with high risk of MRONJ is a user-friendly technique with an excellent cost-benefit ratio in oral surgery.
牙牙槽外科可能是 MRONJ 和拔牙后其他并发症的主要危险因素，尤其是在患有系统性疾病的患者中。本回顾性研究旨在评估拔牙窝中插入 PRF 塞是否可以预防 MRONJ 的发生。根据包括拔牙后是否插入 PRF 的手术方案，将患者分为两组，并分析所有的病史和临床数据。在对照组中，有 5 名患者（19.23%）发生了 MRONJ，而在研究组中，没有报告任何 MRONJ 病例。在对照组中，发生 MRONJ 的患者 CTX 小于 100 pg/mL（5 名高风险患者，Spearman 等级 =.547，<.001）。在 MRONJ 高风险患者中使用血小板浓缩物是一种用户友好的技术，在口腔手术中具有极佳的成本效益比。
