Imperial Centre for Pediatrics and Child Health, Imperial College, St Mary's Campus Norfolk Place, London W2 1PG, UK.
Division of Diabetes, Endocrinology and Metabolism, Imperial College, 6th Floor Commonwealth Building, Hammersmith Campus, DuCane Road, London W12, UK.
Cell Rep Med. 2021 May 18;2(5):100280. doi: 10.1016/j.xcrm.2021.100280.
Case fatality among African children with severe acute malnutrition remains high. We report a 3-arm pilot trial in 58 Ugandan children, comparing feeds targeting disordered gastrointestinal function containing cowpea (CpF, n = 20) or inulin (InF, n = 20) with conventional feeds (ConF, n = 18). Baseline measurements of gut permeability (lactulose:mannitol ratio 1.19 ± SD 2.00), inflammation (fecal calprotectin 539.0 μg/g, interquartile range [IQR] 904.8), and satiety (plasma polypeptide YY 62.6 pmol/l, IQR 110.3) confirm gastrointestinal dysfunction. By day 28, no differences are observable in proportion achieving weight gain >5 g/kg/day (87%, 92%, 86%; p > 0.05), mortality (16%, 30%, 17%; p > 0.05), or edema resolution (83%, 54%, 91%; p > 0.05) among CpF, InF, and ConF. Decreased fecal bacterial richness from day 1 (abundance-based coverage estimator [ACE] 53.2) to day 7 (ACE 40.8) is observed only in ConF (p = 0.025). relative abundance increases from day 7 (5.8% ± 8.6%) to day 28 (10.9% ± 8.7%) in CpF (corrected p = 1.000). Legume-enriched feeds support aspects of gut function and the microbiome. Trial registration PACTR201805003381361.
在患有严重急性营养不良的非洲儿童中，病死率仍然很高。我们报告了一项在 58 名乌干达儿童中进行的 3 臂试验，比较了针对胃肠道功能紊乱的含有豇豆（CpF，n=20）或菊粉（InF，n=20）的饲料与常规饲料（ConF，n=18）。肠道通透性（乳果糖：甘露醇比值 1.19±2.00）、炎症（粪便钙卫蛋白 539.0μg/g，四分位间距 [IQR]904.8）和饱腹感（血浆多肽 YY 62.6 pmol/l，IQR 110.3）的基线测量值证实了胃肠道功能障碍。到第 28 天，体重增加>5 g/kg/d 的比例（87%、92%、86%；p>0.05）、死亡率（16%、30%、17%；p>0.05）或水肿消退（83%、54%、91%；p>0.05）在 CpF、InF 和 ConF 之间没有差异。仅在 ConF 中观察到粪便细菌丰富度从第 1 天（基于丰度的覆盖估计值 [ACE]53.2）到第 7 天（ACE40.8）的减少（p=0.025）。在 CpF 中，相对丰度从第 7 天（5.8%±8.6%）增加到第 28 天（10.9%±8.7%）（校正后 p=1.000）。富含豆类的饲料支持肠道功能和微生物组的各个方面。试验注册 PACTR201805003381361。
Zotero 插件
