载万古霉素卟啉基金属有机框架 PCN-224 增强抗金黄色葡萄球菌的抗菌活性。
Vancomycin-Functionalized Porphyrinic Metal-Organic Framework PCN-224 with Enhanced Antibacterial Activity against Staphylococcus Aureus.
机构信息
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, P. R. China.
Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, P. R. China.
出版信息
Chem Asian J. 2021 Aug 2;16(15):2022-2026. doi: 10.1002/asia.202100546. Epub 2021 Jun 15.
A vancomycin (Van) modification strategy on a porphyrinic metal-organic framework (MOF) PCN-224 is presented. The obtained Van-PCN-224 gives the combined advantages of porphyrinic MOF and Van with high photosensitive activity and excellent targeted antibacterial activity against Staphylococcus aureus. The features make Van-PCN-224 promising for antimicrobial therapy.
本文提出了一种在卟啉金属-有机骨架（MOF）PCN-224 上修饰万古霉素（Van）的策略。所得的 Van-PCN-224 结合了卟啉 MOF 和 Van 的优点，具有高光敏活性和对金黄色葡萄球菌的优异靶向抗菌活性。这些特性使 Van-PCN-224 有望用于抗菌治疗。
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