Zhang Huiru, Xu Zhihao, Mao Ying, Zhang Yingjie, Li Yan, Lao Jihong, Wang Lu
Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai 201620, China.
Key Laboratory of Textile Industry for Biomedical Textile Materials and Technology, Donghua University, Shanghai 201620, China.
Polymers (Basel). 2021 Nov 15;13(22):3942. doi: 10.3390/polym13223942.
The rise and spread of antimicrobial resistance is creating an ever greater challenge in wound management. Nanofibrous membranes (NFMs) incorporated with antibiotics have been widely used to remedy bacterial wound infections owing to their versatile features. However, misuse of antibiotics has resulted in drug resistance, and it remains a significant challenge to achieve both high antibacterial efficiency and without causing bacterial resistance. Here, the 'MOF-first' strategy was adopted, the porphyrinic metal-organic frameworks nanoparticles (PCN-224 NPs) were pre-synthesized first, and then the composite antibacterial PCN-224 NPs @ poly (ε-caprolactone) (PM) NFMs were fabricated via a facile co-electrospinning technology. This strategy allows large amounts of effective MOFs to be integrated into nanofibers to effectively eliminate bacteria without bacterial resistance and to realize a relatively fast production rate. Upon visible light (630 nm) irradiation for 30 min, the PM-25 NFMs have the best O generation performance, triggering remarkable photodynamic antibacterial effects against both , , and bacteria with survival rates of 0.13%, 1.91%, and 2.06% respectively. Considering the photodynamic antibacterial performance of the composite nanofibrous membranes functionalized by porphyrinic MOFs, this simple approach may provide a feasible way to use MOF materials and biological materials to construct wound dressing with the versatility to serve as an antibacterial strategy in order to prevent bacterial resistance.
抗菌耐药性的出现和传播给伤口管理带来了越来越大的挑战。含有抗生素的纳米纤维膜（NFMs）因其多功能特性而被广泛用于治疗细菌性伤口感染。然而，抗生素的滥用导致了耐药性，要实现高抗菌效率且不产生细菌耐药性仍然是一项重大挑战。在此，采用了“MOF优先”策略，首先预合成卟啉金属有机框架纳米颗粒（PCN - 224 NPs），然后通过简便的共电纺丝技术制备复合抗菌PCN - 224 NPs@聚（ε-己内酯）（PM）NFMs。该策略可使大量有效的金属有机框架（MOFs）整合到纳米纤维中，有效消除细菌且不会产生细菌耐药性，并实现相对较快的生产速度。在630 nm可见光照射30分钟后，PM - 25 NFMs具有最佳的单线态氧生成性能，对金黄色葡萄球菌、大肠杆菌和铜绿假单胞菌均引发显著的光动力抗菌效果，存活率分别为0.13%、1.91%和2.06%。考虑到卟啉基金属有机框架功能化的复合纳米纤维膜的光动力抗菌性能，这种简单方法可能为利用金属有机框架材料和生物材料构建具有多功能的伤口敷料提供一种可行途径，作为一种抗菌策略以防止细菌耐药性。
