在恶魔弧菌中发现一种新型质粒介导碳青霉烯酶编码基因 。
Identification of a Novel Plasmid-Mediated Carbapenemase-Encoding Gene, , in Vibrio diabolicus.
机构信息
Department of Marine Biology, College of Oceanography, Hohai University, Nanjing, People's Republic of China.
Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China.
出版信息
Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0020621. doi: 10.1128/AAC.00206-21.
Abstract
Here, we characterized a carbapenem-resistant Vibrio diabolicus strain of shrimp origin with various experiments and bioinformatics analysis. A novel metallo-β-lactamase (MBL) gene, , that confers resistance to β-lactams, including meropenem and cephalosporins, was identified on a plasmid-borne composite transposon, IS-IS---IS, which is capable of generating a -bearing circular intermediate. IS was found to be disseminated in multidrug-resistant (MDR) pathogens, arousing the concern of further transmission of a -bearing circular intermediate to clinical Enterobacterales strains via such insertion sequences, which warrants further investigations.
摘要
在这里，我们通过各种实验和生物信息学分析，对一种具有虾源的耐碳青霉烯类霍乱弧菌进行了表征。在一个质粒携带的复合转座子 IS-IS---IS 上，发现了一个新的金属β-内酰胺酶（MBL）基因 ，该基因能够产生携带的环状中间产物，从而赋予了对β-内酰胺类药物（包括美罗培南和头孢菌素类药物）的耐药性。发现 IS 广泛存在于多种耐药（MDR）病原体中，这引起了人们对通过这种插入序列将携带的环状中间产物进一步传播到临床肠杆菌科菌株的担忧，这需要进一步的研究。
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