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An updated phylogeny of the metallo-β-lactamases.金属β-内酰胺酶的系统发育更新。
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2
Integrated chromosomal and plasmid sequence analyses reveal diverse modes of carbapenemase gene spread among .整合染色体和质粒序列分析揭示碳青霉烯酶基因在. 中的多种传播模式
Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):25043-25054. doi: 10.1073/pnas.2003407117. Epub 2020 Sep 23.
3
ResFinder 4.0 for predictions of phenotypes from genotypes.ResFinder 4.0 用于基因型到表型的预测。
J Antimicrob Chemother. 2020 Dec 1;75(12):3491-3500. doi: 10.1093/jac/dkaa345.
4
Deciphering the Structural Diversity and Classification of the Mobile Tigecycline Resistance Gene (X)-Bearing Plasmidome among Bacteria.解析细菌中携带移动替加环素抗性基因（X）的质粒组的结构多样性与分类
mSystems. 2020 Apr 28;5(2):e00134-20. doi: 10.1128/mSystems.00134-20.
5
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Adv Biosyst. 2020 Mar;4(3):e1900221. doi: 10.1002/adbi.201900221. Epub 2020 Jan 29.
6
Epidemiology of β-Lactamase-Producing Pathogens.产β-内酰胺酶病原体的流行病学。
Clin Microbiol Rev. 2020 Feb 26;33(2). doi: 10.1128/CMR.00047-19. Print 2020 Mar 18.
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Comparative Genomic Analysis of and Six Taxonomic Synonyms: A First Look at the Distribution and Diversity of the Expanded Species.[物种名称]及其六个分类学同义词的比较基因组分析：对扩展物种分布和多样性的初步观察。 （你提供的原文中“of”后面缺少具体物种名称，我根据格式猜测补充了[物种名称]，你可根据实际情况修改）
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Pushing the limits of de novo genome assembly for complex prokaryotic genomes harboring very long, near identical repeats.为含有超长、近乎完全相同重复序列的复杂原核基因组的从头基因组组装推陈出新。
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Efficient generation of complete sequences of MDR-encoding plasmids by rapid assembly of MinION barcoding sequencing data.通过快速组装 MinION 条形码测序数据，高效生成完整的 MDR 编码质粒序列。
Gigascience. 2018 Mar 1;7(3):1-9. doi: 10.1093/gigascience/gix132.
10
Unicycler: Resolving bacterial genome assemblies from short and long sequencing reads.单轮循环器：从短读长和长读长测序数据中解析细菌基因组组装结果
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在恶魔弧菌中发现一种新型质粒介导碳青霉烯酶编码基因 。

Identification of a Novel Plasmid-Mediated Carbapenemase-Encoding Gene, , in Vibrio diabolicus.

机构信息

Department of Marine Biology, College of Oceanography, Hohai University, Nanjing, People's Republic of China.

Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China.

出版信息

Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0020621. doi: 10.1128/AAC.00206-21.

DOI:10.1128/AAC.00206-21
PMID:34097496
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8284434/
Abstract

Here, we characterized a carbapenem-resistant Vibrio diabolicus strain of shrimp origin with various experiments and bioinformatics analysis. A novel metallo-β-lactamase (MBL) gene, , that confers resistance to β-lactams, including meropenem and cephalosporins, was identified on a plasmid-borne composite transposon, IS-IS---IS, which is capable of generating a -bearing circular intermediate. IS was found to be disseminated in multidrug-resistant (MDR) pathogens, arousing the concern of further transmission of a -bearing circular intermediate to clinical Enterobacterales strains via such insertion sequences, which warrants further investigations.

摘要

在这里，我们通过各种实验和生物信息学分析，对一种具有虾源的耐碳青霉烯类霍乱弧菌进行了表征。在一个质粒携带的复合转座子 IS-IS---IS 上，发现了一个新的金属β-内酰胺酶（MBL）基因 ，该基因能够产生携带的环状中间产物，从而赋予了对β-内酰胺类药物（包括美罗培南和头孢菌素类药物）的耐药性。发现 IS 广泛存在于多种耐药（MDR）病原体中，这引起了人们对通过这种插入序列将携带的环状中间产物进一步传播到临床肠杆菌科菌株的担忧，这需要进一步的研究。