Novel Bacteria and Drug Discovery Research Group (NBDD), Microbiome and Bioresource Research Strength (MBRS), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor Darul Ehsan 47500, Malaysia.
Clinical School Johor Bahru, Jeffry Cheah School of Medicine and Health Sciences, Monash University Malaysia, Johor Bahru 80100, Malaysia.
Int J Mol Sci. 2022 Oct 18;23(20):12486. doi: 10.3390/ijms232012486.
The increasing prevalence of resistance in carbapenems is an escalating concern as carbapenems are reserved as last-line antibiotics. Although indiscriminate antibiotic usage is considered the primary cause for resistance development, increasing evidence revealed that inconsequential strains without any direct clinical relevance to carbapenem usage are harboring carbapenemase genes. This phenomenon indirectly implies that environmental microbial populations could be the 'hidden vectors' propelling carbapenem resistance. This work aims to explore the carbapenem-resistance profile of species across diverse settings. This review then proceeds to identify the different factors contributing to the dissemination of the resistance traits and defines the transmission pathways of carbapenem resistance. Deciphering the mechanisms for carbapenem resistance acquisition could help design better prevention strategies to curb the progression of antimicrobial resistance development. To better understand this vast reservoir selecting for carbapenem resistance in non-clinical settings, species is also prospected as one of the potential indicator strains for carbapenem resistance in the environment.
碳青霉烯类耐药性的不断增加令人担忧，因为碳青霉烯类药物被保留作为最后一线抗生素。虽然人们认为滥用抗生素是耐药性发展的主要原因，但越来越多的证据表明，与碳青霉烯类药物使用没有直接临床相关性的无关紧要的菌株也携带有碳青霉烯酶基因。这种现象间接表明，环境微生物种群可能是推动碳青霉烯类耐药性的“隐性载体”。本研究旨在探索不同环境中 种的碳青霉烯类耐药情况。本综述接着确定了导致耐药性传播的不同因素，并定义了碳青霉烯类耐药性的传播途径。解析碳青霉烯类耐药性获得的机制有助于设计更好的预防策略，以遏制抗菌药物耐药性的发展。为了更好地理解这一巨大的耐药性选择库，在非临床环境中， 种也被认为是环境中碳青霉烯类耐药性的潜在指示菌株之一。
