Institute of Plant Breeding and Genetic Resources, ELGO-Dimitra (ex NAGREF), 57001, Thessaloniki, Greece.
Laboratory of Pomology, Department of Agriculture, Aristotle University of Thessaloniki, 57001, Thessaloniki, Greece.
Mol Biol Rep. 2021 May;48(5):4441-4448. doi: 10.1007/s11033-021-06464-0. Epub 2021 Jun 7.
There is a persistent interest in innovative and multifunctional ingredients in biology research. With regards to this, natural sources have an important role due to their multiple benefits. Thus, this study aims to present the pleiotropic activity of Prunus avium L. extract on human primary fibroblasts for proving its efficacy in dermis-related processes. We focused on the safety and efficacy assessments based on cytotoxicity and gene expression analysis under oxidative stress. Specifically, Prunus avium L. extract was proved non-cytotoxic in human fibroblasts. The gene expression analysis unveiled that this extract has in vitro protective properties on human dermal fibroblasts under oxidative stress related to antioxidant activity, anti-inflammatory response, cell proliferation and cell- aging. Our study demonstrated for the very first time that the Prunus avium L. extract is a multifunctional ingredient as it mediates several human dermis-related in vitro processes highlighting its potential to be used as an active ingredient in skin care products.
人们对生物学研究中的创新和多功能成分一直很感兴趣。在这方面，由于天然来源具有多种益处，因此它们具有重要作用。因此，本研究旨在介绍欧洲甜樱桃（Prunus avium L.）提取物对人原代成纤维细胞的多效活性，以证明其在真皮相关过程中的功效。我们专注于基于细胞毒性和氧化应激下的基因表达分析的安全性和功效评估。具体而言，已证明欧洲甜樱桃（Prunus avium L.）提取物对人成纤维细胞无毒。基因表达分析表明，该提取物在与抗氧化活性、抗炎反应、细胞增殖和细胞衰老相关的氧化应激下对人真皮成纤维细胞具有体外保护作用。我们的研究首次证明，欧洲甜樱桃（Prunus avium L.）提取物是一种多功能成分，因为它介导了几种与人类真皮相关的体外过程，突出了其在护肤品中的应用潜力。
