在帕金森病和其他帕金森综合征中对黑质进行成像。
Imaging the Substantia Nigra in Parkinson Disease and Other Parkinsonian Syndromes.
机构信息
From the Departments of Radiology (Y.J.B., B.S.C., S.J.C., J.H.K.), Neurology (J.M.K., J.H.C.), and Nuclear Medicine (Y.S.S.), Seoul National University Bundang Hospital, Seoul National University College of Medicine, 173-82 Gumi-ro, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Republic of Korea; Departments of Radiology (C.H.S.) and Neurology (B.J.), Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea; and Division of Biomedical Engineering, Hankuk University of Foreign Studies, Yongin, Republic of Korea (Y.N.).
出版信息
Radiology. 2021 Aug;300(2):260-278. doi: 10.1148/radiol.2021203341. Epub 2021 Jun 8.
Parkinson disease is characterized by dopaminergic cell loss in the substantia nigra of the midbrain. There are various imaging markers for Parkinson disease. Recent advances in MRI have enabled elucidation of the underlying pathophysiologic changes in the nigral structure. This has contributed to accurate and early diagnosis and has improved disease progression monitoring. This article aims to review recent developments in nigral imaging for Parkinson disease and other parkinsonian syndromes, including nigrosome imaging, neuromelanin imaging, quantitative iron mapping, and diffusion-tensor imaging. In particular, this article examines nigrosome imaging using 7-T MRI and 3-T susceptibility-weighted imaging. Finally, this article discusses volumetry and its clinical importance related to symptom manifestation. This review will improve understanding of recent advancements in nigral imaging of Parkinson disease. Published under a CC BY 4.0 license.
帕金森病的特征是中脑黑质多巴胺能神经元丧失。有多种成像标志物可用于帕金森病。磁共振成像的最新进展使人们能够阐明黑质结构的潜在病理生理变化。这有助于进行准确和早期诊断，并改善疾病进展监测。本文旨在综述帕金森病和其他帕金森综合征的黑质成像的最新进展，包括黑质体成像、神经黑色素成像、定量铁成像和弥散张量成像。特别是，本文研究了使用 7-T MRI 和 3-T 磁化率加权成像的黑质体成像。最后，本文讨论了与症状表现相关的容积测量及其临床重要性。本综述将提高对帕金森病黑质成像最新进展的认识。发表于 CC BY 4.0 许可下。
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