Xiang Xinran M, Hollen Chris, Yang Qian, Brumbach Barbara H, Spain Rebecca I, Wooliscroft Lindsey
Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
OHSU-PSU School of Public Health, Oregon Health & Science University, Portland, OR, USA.
Mult Scler J Exp Transl Clin. 2021 May 31;7(2):20552173211017159. doi: 10.1177/20552173211017159. eCollection 2021 Apr-Jun.
Hesitancy to receive COVID-19 vaccination is a major public health concern. COVID-19 vaccine willingness and the factors contributing to willingness in adults with multiple sclerosis (MS) is unknown. We administered an online survey from 1 December 2020 to 7 January 2021 to adults with MS to estimate COVID-19 vaccine willingness among adults with MS. Bivariate analysis with chi-square testing compared categorical variables associated with vaccine willingness.
Of 401 respondents, 70.1% were willing to receive an authorized COVID-19 vaccination if it was available to them, 22.7% were unsure, and 7.2% were unwilling. The most frequent concern for those unsure was vaccine safety. Vaccine willingness was associated with increased perceived personal risk of COVID-19 (χ = 45.4; < 0.0001), prior influenza vaccine acceptance (χ = 97.6; < 0.0001), higher educational level (χ = 50.2; < 0.0001), and if respondents discussed or planned to discuss the COVID-19 vaccine with their neurologists (χ = 64.3; < 0.0001).
While COVID-19 vaccination willingness is high among people with MS, nearly 30% were either unwilling or unsure about being vaccinated. Neurologists should be aware of patient-centered factors associated with COVID-19 vaccine willingness and address COVID-19 vaccine safety concerns in discussions with their vaccine-unsure MS patients.
对新冠病毒疫苗接种的犹豫是一个重大的公共卫生问题。多发性硬化症（MS）成人患者的新冠病毒疫苗接种意愿以及影响意愿的因素尚不清楚。我们在2020年12月1日至2021年1月7日对MS成人患者进行了一项在线调查，以评估MS成人患者的新冠病毒疫苗接种意愿。采用卡方检验的双变量分析比较了与疫苗接种意愿相关的分类变量。
在401名受访者中，70.1%的人表示如果有授权的新冠病毒疫苗可供接种，他们愿意接种；22.7%的人不确定；7.2%的人不愿意。那些不确定的人最常见的担忧是疫苗安全性。疫苗接种意愿与感知到的个人感染新冠病毒风险增加（χ=45.4；<0.0001）、之前接受流感疫苗接种（χ=97.6；<0.0001）、教育水平较高（χ=50.2；<0.0001）以及受访者是否与他们的神经科医生讨论过或计划讨论新冠病毒疫苗（χ=64.3；<0.0001）有关。
虽然MS患者对新冠病毒疫苗接种的意愿较高，但近30%的人不愿意或不确定是否接种疫苗。神经科医生应了解与新冠病毒疫苗接种意愿相关的以患者为中心的因素，并在与对疫苗接种不确定的MS患者讨论时解决他们对新冠病毒疫苗安全性的担忧。
