Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine.
Department of Gastroenterology, National Hospital Organization Kyoto Medical Center, Kyoto.
J Clin Gastroenterol. 2022 Mar 1;56(3):e216-e221. doi: 10.1097/MCG.0000000000001577.
This study investigated whether gastric hyperplastic polyps (GHPs) shrink after discontinuation of proton pump inhibitor (PPI) alone.
Long-term use of PPIs has been reported to increase the incidence of GHPs, which sometimes bleed and cause anemia. We experienced a patient whose recurrent hemorrhagic GHPs associated with long-term use of PPIs had disappeared after discontinuation of PPIs.
This study was conducted retrospectively at Kyoto University Hospital. Patients with histologically confirmed GHPs who had been taking PPIs for >6 months and who had undergone a repeat endoscopy within 2 years were included. Polyp shrinkage was defined as the disappearance of polyps or a reduction of >50% in the long diameter of the largest polyp.
Six patients who discontinued PPIs were compared with 17 patients who continued PPIs. Polyp shrinkage was significantly more frequent in the PPI-discontinuation group (5/6, 83%) than in the PPI continuation group (0/17, 0%) (P<0.001). In 2 patients in the PPI-discontinuation group, the polyps completely disappeared finally.
These findings suggest that discontinuation of PPIs can shrink GHPs in patients using PPIs.
本研究旨在探讨质子泵抑制剂 (PPI) 单独停药后胃增生性息肉 (GHPs) 是否会缩小。
长期使用 PPI 已被报道会增加 GHPs 的发生率，GHPs 有时会出血并导致贫血。我们遇到一位患者，由于长期使用 PPI，其反复出血的 GHPs 在停止使用 PPI 后消失了。
本研究在京都大学医院进行回顾性研究。纳入了经组织学证实的 GHPs 患者，这些患者已服用 PPI > 6 个月，并在 2 年内进行了重复内镜检查。息肉缩小定义为息肉消失或最大息肉长径缩小 > 50%。
比较了 6 名停止使用 PPI 的患者和 17 名继续使用 PPI 的患者。在 PPI 停药组（5/6，83%）中，息肉缩小的频率明显高于 PPI 继续使用组（0/17，0%）（P<0.001）。在 PPI 停药组的 2 名患者中，息肉最终完全消失。
这些发现表明，停止使用 PPI 可使使用 PPI 的患者的 GHPs 缩小。
