Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China.
J Clin Periodontol. 2021 Aug;48(8):1076-1084. doi: 10.1111/jcpe.13483. Epub 2021 Jun 9.
The aim of this meta-analysis and Mendelian randomization (MR) study was to assess the association between short sleep and periodontal disease, including tooth loss and periodontitis.
The meta-analysis of relevant studies was conducted to assess the association between short sleep and periodontal disease. MR analyses were conducted with the inverse-variance-weighted (IVW) method, weighted median method, MR-Egger method, and MR-Robust Adjusted Profile Score (RAPS) method to assess the causal effect of short sleep on tooth loss and periodontitis.
Seven cross-sectional studies involving 40,196 individuals were included in the meta-analysis. The association between short sleep and periodontal disease was not statistically significant (odds ratios (OR) =1.13, 95% confidence interval (CI): 0.99, 1.28; p = 0.076). In the MR analysis, we did not observe statistically significant causal associations of genetically determined short sleep with tooth loss (β: -0.056; 95% CI: -0.181 to 0.068; p = 0.376) and periodontitis (β: -0.112; 95% CI: -0.340 to 0.117; p = 0.339).
Short sleep is not associated with the risk of periodontal disease according to current evidence. Future studies need to pay attention to the measurement of sleep duration, the choice of statistical models, and other domains of sleep health.
本荟萃分析和孟德尔随机化（MR）研究的目的是评估短睡眠与牙周病（包括牙齿缺失和牙周炎）之间的关联。
进行了相关研究的荟萃分析，以评估短睡眠与牙周病之间的关联。使用逆方差加权（IVW）法、加权中位数法、MR-Egger 法和 MR-Robust Adjusted Profile Score（RAPS）法进行 MR 分析，以评估短睡眠对牙齿缺失和牙周炎的因果效应。
纳入了 7 项涉及 40196 人的横断面研究进行荟萃分析。短睡眠与牙周病之间的关联无统计学意义（比值比（OR）=1.13，95%置信区间（CI）：0.99，1.28；p=0.076）。在 MR 分析中，我们没有观察到遗传短睡眠与牙齿缺失（β：-0.056；95% CI：-0.181 至 0.068；p=0.376）和牙周炎（β：-0.112；95% CI：-0.340 至 0.117；p=0.339）之间存在统计学显著的因果关联。
根据现有证据，短睡眠与牙周病的风险无关。未来的研究需要注意睡眠持续时间的测量、统计模型的选择以及其他睡眠健康领域。
