Chanarin I, Stephenson E
Department of Haematology, Medical Research Council Clinical Research Centre, Northwick Park Hospital, Harrow.
J Clin Pathol. 1988 Jul;41(7):759-62. doi: 10.1136/jcp.41.7.759.
To determine whether the high incidence of tuberculosis among Asiatic Indians in the United Kingdom was due to impaired killing of Mycobacterium tuberculosis by macrophages from patients deficient in cobalamin, a nutritional survey was carried out among 1187 Indians and the incidence of tuberculosis determined from medical records. The question asked was whether tuberculosis was significantly more common among life-long vegetarians compared with omnivores. The incidence of tuberculosis in vegetarians was 133 in 1000 and that in subjects on mixed diets 48 in 1000. These findings lend support to the hypothesis that dietary factors are of major importance in determining the susceptibility of Asiatic Indians to tuberculosis.
为了确定英国亚裔印度人结核病高发是否是由于钴胺素缺乏患者的巨噬细胞对结核分枝杆菌的杀伤能力受损，对1187名印度人进行了一项营养调查，并根据医疗记录确定了结核病的发病率。所提出的问题是，与杂食者相比，终身素食者中结核病是否明显更为常见。素食者中结核病的发病率为千分之133，混合饮食者中为千分之48。这些发现支持了这样一种假说，即饮食因素在决定亚裔印度人对结核病的易感性方面至关重要。
