Department of Veterinary Medicine, College of Veterinary Medicine, National Chung Hsing University, Taichung, Taiwan.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.
Vet Q. 2021 Dec;41(1):210-216. doi: 10.1080/01652176.2021.1941397.
Renal cortical anisotropy backscattering artifact (CABA) is a focal hyperechoic region where the tubules are parallel to the incident ultrasound beam, reflecting most of the beams to the transducer. To investigate the association between chronic kidney disease (CKD) and the absence of renal CABA in cats. Ultrasonographic renal images of 40 cats with CKD (stage II-IV) and 36 clinically healthy cats were blindly evaluated by two observers to determine the visibility of renal CABA. Inter- and intraobserver agreements were evaluated using McNemar's test. The association between the absence of renal CABA and CKD was assessed using Fisher's exact test. Excellent intraobserver and substantial interobserver agreements were demonstrated. A significant association ( < .0001) between absent renal CABA and CKD stage was revealed in all cats. Cats with CKD had an increased risk of the absence of renal CABA (Odds ratio, 56.0; 95% CI, 13.8-227.0) compared with the clinically healthy cats. The absence of renal CABA revealed 87.5% sensitivity and 88.9% specificity to detect CKD in all cats, and 91.7% sensitivity and 83.3% specificity in aged cats. Our study demonstrated a correlation between feline CKD and the absence of renal CABA, providing a feasible and alternative method for feline CKD evaluation.
肾脏皮质各向异性背向散射伪像（CABA）是一个局灶性高回声区域，其中肾小管与入射超声束平行，将大部分光束反射到换能器。本研究旨在探讨猫慢性肾脏病（CKD）与肾脏 CABA 缺失之间的关系。对 40 例 CKD（Ⅱ-Ⅳ期）猫和 36 例临床健康猫的肾脏超声图像进行了两位观察者的盲法评估，以确定肾脏 CABA 的可见性。采用 McNemar 检验评估观察者间和观察者内的一致性。采用 Fisher 确切检验评估肾脏 CABA 缺失与 CKD 的相关性。结果显示，观察者间和观察者内具有极好的一致性。在所有猫中，均显示出肾脏 CABA 缺失与 CKD 分期之间存在显著相关性（<.0001）。与临床健康猫相比，患有 CKD 的猫肾脏 CABA 缺失的风险显著增加（优势比，56.0；95%CI，13.8-227.0）。在所有猫中，肾脏 CABA 缺失检测 CKD 的灵敏度为 87.5%，特异性为 88.9%，在老年猫中，灵敏度为 91.7%，特异性为 83.3%。本研究表明，猫 CKD 与肾脏 CABA 缺失之间存在相关性，为猫 CKD 的评估提供了一种可行的替代方法。
