Tower Hamlets Centre for Mental Health, Bancroft Rd, London, E1 4DG, UK.
American Clinic Tokyo, Niikura Building 3F, 1-7-4 Akasaka, Minato, Tokyo, 107-0052, Japan.
Health Qual Life Outcomes. 2021 Jun 12;19(1):163. doi: 10.1186/s12955-020-01654-z.
An automated web-based assessment and monitoring system ( www.psynary.com ) has been developed to assist non-specialist clinicians in managing common mood and anxiety disorders. Psynary promotes the use of standardised outcome measures to assess symptom severity and optimise treatments with the aim of improving outcomes and enabling faster recovery. This paper analyses the results from two parallel studies in New Zealand and Japan (OptiMA-1 NZ and Japan) to assess the validity of the R8 Depression scale, one of the system's core outcome measures.
Clinical samples were recruited from a public secondary care and a private psychiatry clinic. Participants completed the outcome measures for the study via the online Psynary system. The R8 Depression scale is a 30-item questionnaire which includes all symptom domains covered in the ICD-10 classification of depression. The Patient Health Questionnaire (PHQ-9) was completed at the same time points as the R8 Depression, with a smaller sample also completing a paper-based Quick Inventory of Depressive Symptomatology (QIDS-SR16). Internal validity was quantified via Cronbach's alpha and Guttman lower bounds method. External validation against the PHQ-9 and QIDS used the Pearson's and Kendall's correlation coefficients. Severity categories were set using a multivariate regression model.
270 patients participated in the study and completed a maximum of 1 baseline and 5 reviews within a 90-day period, giving a total of 1124 assessments with the PHQ-9 also being completed in 1053 of these assessments. R8 Depression normative data was also collected from 204 non-clinical volunteers with 187 of these also completing the PHQ9. Internal reliability scores were all higher than 0.9 (n = 1328). There was overall good external validity when comparing the R8 Depression to the PHQ-9, with a correlation of 0.91 for the combined normative and clinical samples (n = 1240).
The R8 Depression has been developed as a patient-rated outcome measure for depression for administration on an online system called "Psynary". It has high internal and external validity against current widely used scales. Further work is underway to determine the sensitivity to change of the R8 Depression.
一个自动化的基于网络的评估和监测系统（www.psynary.com）已经被开发出来，以帮助非专业临床医生管理常见的情绪和焦虑障碍。Psynary 提倡使用标准化的结果测量来评估症状的严重程度，并优化治疗，以改善结果并实现更快的康复。本文分析了新西兰和日本的两项平行研究（OptiMA-1 NZ 和日本）的结果，以评估该系统的核心结果测量之一 R8 抑郁量表的有效性。
临床样本是从一家公立二级保健机构和一家私人精神病诊所招募的。参与者通过在线 Psynary 系统完成研究的结果测量。R8 抑郁量表是一个 30 项的问卷，其中包括 ICD-10 抑郁分类中涵盖的所有症状领域。同时，患者健康问卷（PHQ-9）也在同一时间点与 R8 抑郁量表一起完成，较小的样本还完成了纸质版的快速抑郁症状清单（QIDS-SR16）。内部有效性通过 Cronbach's alpha 和 Guttman 下限方法进行量化。与 PHQ-9 和 QIDS 的外部验证使用 Pearson 和 Kendall 相关系数。严重程度类别是使用多元回归模型设置的。
共有 270 名患者参加了这项研究，在 90 天内最多完成了 1 次基线和 5 次复查，总共进行了 1124 次评估，其中 1053 次评估也同时完成了 PHQ-9。204 名非临床志愿者也完成了 R8 抑郁的正常数据收集，其中 187 名志愿者也完成了 PHQ9。内部可靠性评分均高于 0.9（n=1328）。当将 R8 抑郁与 PHQ-9 进行比较时，整体上具有良好的外部有效性，综合正常和临床样本的相关性为 0.91（n=1240）。
R8 抑郁量表已被开发为一种在线系统“Psynary”上的患者自评抑郁结果测量工具。它与当前广泛使用的量表具有高度的内部和外部有效性。正在进行进一步的工作以确定 R8 抑郁量表对变化的敏感性。
