Greenhalgh D G, Gamelli R L
University of Washington, Department of Surgery, Seattle 98105.
J Surg Res. 1988 Sep;45(3):261-5. doi: 10.1016/0022-4804(88)90073-x.
Adriamycin-impaired wound healing in mice was found to be related to the degree of weight loss which in turn was dependent on the dose given. Treated animals had an initial decrease in food consumption that correlated with initial weight loss. After approximately 7 days, food consumption returned to normal but the weight loss persisted. Both Adriamycin-treated mice and animals pair fed the amount of food consumed by drug-treated mice had wounds significantly weaker than control animals at 7 and 11 days. The Adriamycin-treated animals had 11-day wound strengths equal to or weaker than the pair fed group. By Day 14, the pair fed animals had wounds similar to those of controls but the Adriamycin-treated animals remained significantly weaker than the other groups. We feel that initially Adriamycin produces a short-term nutritional deficit that contributes to early wound healing impairment. Later, the toxicity of the drug predominates in altering wound repair.
已发现阿霉素会损害小鼠的伤口愈合，这与体重减轻程度有关，而体重减轻程度又取决于给药剂量。接受治疗的动物最初食物摄入量减少，这与最初的体重减轻相关。大约7天后，食物摄入量恢复正常，但体重减轻仍持续。在第7天和第11天，阿霉素治疗的小鼠以及按药物治疗小鼠的食物摄入量进行配对喂养的动物，其伤口明显比对照动物弱。阿霉素治疗的动物在第11天的伤口强度等于或弱于配对喂养组。到第14天，配对喂养的动物伤口与对照组相似，但阿霉素治疗的动物伤口仍明显比其他组弱。我们认为，最初阿霉素会产生短期营养缺乏，这会导致早期伤口愈合受损。后来，药物的毒性在改变伤口修复方面占主导地位。
