Johnson H, Parham M, Davis E, Wise L
Department of Surgery, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, NY 11042.
J Invest Surg. 1991;4(3):313-22. doi: 10.3109/08941939109141163.
The effect of nifedipine, an oral calcium-channel blocker, on adriamycin-induced wound healing was studied. Nifedipine was administered to animals prior to treating with adriamycin. The healing strengths of cecal, fascial, and skin anatomoses were measured. Animals treated with adriamycin alone had significant decreases in healing strength compared to controls: for cecum at postoperative days (POD) 7 and 14; for skin at PODs 14, 21, and 28; for fascia at POD 28. Overall, nifedipine reduced the impact of adriamycin injury on the strength of healing incisional anastomoses. Nifedipine also appeared to protect collagen synthesis at anastomotic sites from adriamycin-induced impairment.
研究了口服钙通道阻滞剂硝苯地平对阿霉素诱导的伤口愈合的影响。在给予动物阿霉素治疗之前先给予硝苯地平。测量盲肠、筋膜和皮肤吻合处的愈合强度。与对照组相比，单独用阿霉素治疗的动物愈合强度显著降低：盲肠在术后第7天和第14天；皮肤在术后第14天、21天和28天；筋膜在术后第28天。总体而言，硝苯地平减轻了阿霉素损伤对切口吻合处愈合强度的影响。硝苯地平似乎还能保护吻合部位的胶原蛋白合成免受阿霉素诱导的损害。
