Devereux D F, Thibault L, Boretos J, Brennan M F
Cancer. 1979 Mar;43(3):932-8. doi: 10.1002/1097-0142(197903)43:3<932::aid-cncr2820430322>3.0.co;2-a.
Clinical impression suggests that Adriamycin (ADR) interferes with wound healing. To examine the effects of ADR on wound healing, male Fischer rats were subjected to a dorsal, midline, full-thickness longitudinal incision (day 0). Wound clips were removed on day +7. Twenty animals per group were given intravenous ADR on day -7, day 0, day +3 and day +7. Twenty animals served as non-treated, wounded controls (C). Five animals/group were sacrificed on days +7, +14 and +21, at which time two 9.5 mm wide strips were taken from each animal perpendicular to the wound axis and submitted for wound breaking strength (WBS) measurements and load-extension curve analysis. WBS differed most markedly at Day 21 between C(1671 +/- 59g) and ADR day -7(1360 + 71 g) p less than 0.01; C and ADR day 0 (1051 +/- 108 g) p less than 0.001; C and ADR day + 3(1134 +/- 176 g) p less than 0.02. No difference existed between C and day +7 (1790 +/- 153 g). A point of inflection always occurred between 55-60% elongation in ADR treated animals only. This portion of the curve has been previously shown to represent collagen content. It is concluded that perioperative ADR administration (day -7 through day +3) significantly and substantially impairs skin wound healing in the rat. A form of collagen yielding underlies and may contribute to this defect.
临床观察表明阿霉素（ADR）会干扰伤口愈合。为了研究ADR对伤口愈合的影响，对雄性Fischer大鼠进行背部中线全层纵向切口手术（第0天）。在第7天拆除伤口夹。每组20只动物在第-7天、第0天、第+3天和第+7天静脉注射ADR。另外20只动物作为未治疗的伤口对照（C组）。每组5只动物在第+7天、+14天和+21天处死，此时从每只动物身上垂直于伤口轴线取两条9.5毫米宽的组织条，用于测量伤口抗张强度（WBS）并进行负荷-伸长曲线分析。在第21天，C组（1671±59克）与ADR第-7天组（1360 + 71克）的WBS差异最为显著，p<0.01；C组与ADR第0天组（1051±108克）比较，p<0.001；C组与ADR第+3天组（1134±176克）比较，p<0.02。C组与第+7天组（1790±153克）之间无差异。仅在接受ADR治疗的动物中，伸长率在55%-60%之间时总是出现一个拐点。曲线的这一部分先前已被证明代表胶原蛋白含量。结论是围手术期给予ADR（第-7天至第+3天）会显著且实质性地损害大鼠皮肤伤口愈合。一种胶原蛋白屈服形式是这种缺陷的基础并可能导致该缺陷。
