Wang Peng, Zhou Fang, Guan Kesong, Wang Youjuan, Fu Xiaoyi, Yang Yue, Yin Xia, Song Guosheng, Zhang Xiao-Bing, Tan Weihong
Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Life Sciences, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University Changsha Hunan 410082 China
Chem Sci. 2019 Dec 3;11(5):1299-1306. doi: 10.1039/c9sc04875h.
The real-time and monitoring of reactive oxygen species (ROS) generation is critical for minimizing the nonspecific damage derived from the high doses of ROS required during the photodynamic therapy (PDT) process. However, phototherapeutic agents that can generate ROS-related imaging signals during PDT are rare, hampering the facile prediction of the future therapeutic outcome. Herein, we develop an upconverting covalent organic framework (COF) nanoplatform a core-mediated strategy and further functionalized it with a singlet oxygen reporter for the efficient near-infrared activated and self-reporting of PDT. In this work, the COF photodynamic efficacy is greatly improved (12.5 times that of irregular COFs) tailoring the size. Furthermore, this nanoplatform is able to not only produce singlet oxygen for PDT, but it can also emit singlet oxygen-correlated luminescence, allowing the real-time and monitoring of the therapeutic process for cancer cells or solid tumors near-infrared luminescence imaging. Thus, our core-mediated synthetic and size-tailored strategy endows the upconverting COF nanoplatform with promising abilities for high-efficacy, deep-tissue, precise photodynamic treatment.
实时监测活性氧（ROS）的生成对于将光动力疗法（PDT）过程中所需高剂量ROS产生的非特异性损伤降至最低至关重要。然而，在PDT期间能够产生活性氧相关成像信号的光治疗剂很少，这阻碍了对未来治疗结果的轻松预测。在此，我们开发了一种上转换共价有机框架（COF）纳米平台——一种核心介导策略，并进一步用单线态氧报告分子对其进行功能化，以实现高效的近红外激活和PDT的自报告。在这项工作中，通过调整尺寸，COF的光动力疗效得到了极大提高（是不规则COF的12.5倍）。此外，这种纳米平台不仅能够为PDT产生单线态氧，还能发出与单线态氧相关的发光，从而通过近红外发光成像对癌细胞或实体瘤的治疗过程进行实时监测。因此，我们的核心介导合成和尺寸定制策略赋予了上转换COF纳米平台高效、深部组织、精确光动力治疗的潜力。
