Wang Liang, Didelot Xavier, Bi Yuhai, Gao George F
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing 100101, China.
School of Life Sciences and Department of Statistics, University of Warwick, Coventry CV4 7AL, UK.
Innovation (Camb). 2021 Aug 28;2(3):100128. doi: 10.1016/j.xinn.2021.100128. Epub 2021 Jun 7.
SARS-CoV-2 has recently been found to have spread from humans to minks and then to have transmitted back to humans. However, it is unknown to what extent the human-to-human transmission caused by the variant has reached. Here, we used publicly available SARS-CoV-2 genomic sequences from both humans and minks collected in Denmark and the Netherlands, and combined phylogenetic analysis with Bayesian inference under an epidemiological model, to trace the possibility of person-to-person transmission. The results showed that at least 12.5% of all people being infected with dominated mink-derived SARS-CoV-2 variants in Denmark and the Netherlands were caused by human-to-human transmission, indicating that this "back-to-human" SARS-CoV-2 variant has already caused human-to-human transmission. Our study also indicated the need for monitoring this mink-derived and other animal source "back-to-human" SARS-CoV-2 in future and that prevention and control measures should be tailored to avoid large-scale community transmission caused by the virus jumping between animals and humans.
最近发现严重急性呼吸综合征冠状病毒2（SARS-CoV-2）已从人类传播到水貂，然后又传播回人类。然而，这种变体导致的人际传播程度尚不清楚。在此，我们使用了丹麦和荷兰收集的人类和水貂的公开可用SARS-CoV-2基因组序列，并在流行病学模型下将系统发育分析与贝叶斯推理相结合，以追踪人际传播的可能性。结果表明，在丹麦和荷兰，感染主要来自水貂的SARS-CoV-2变体的所有人中，至少12.5%是由人际传播引起的，这表明这种“回传至人类”的SARS-CoV-2变体已经导致了人际传播。我们的研究还表明，未来需要监测这种源自水貂和其他动物源的“回传至人类”的SARS-CoV-2，并且应制定预防和控制措施，以避免该病毒在动物和人类之间传播导致大规模社区传播。
