Sigal L H, Tatum A H
Medical Service, VAMC-Syracuse.
Neurology. 1988 Sep;38(9):1439-42. doi: 10.1212/wnl.38.9.1439.
Serum from patients with neurologic manifestations of Lyme disease had serum IgM antibodies that bound to normal human axons, whereas binding was absent or weak in patients without neurologic findings. Antiaxonal binding could be eliminated by absorption with Borrelia burgdorferi. A murine monoclonal antibody to the borrelial flagellin also bound to human axons.
莱姆病有神经学表现的患者血清中的IgM抗体可与正常人轴突结合，而无神经学表现的患者血清则无此结合或结合较弱。轴突结合可通过用伯氏疏螺旋体吸收而消除。一种针对螺旋体鞭毛蛋白的鼠单克隆抗体也可与人轴突结合。
