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模拟 COVID-19 大流行期间英格兰腹主动脉瘤筛查和治疗服务变化的影响。

Modelling the impact of changes to abdominal aortic aneurysm screening and treatment services in England during the COVID-19 pandemic.

机构信息

Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom.

Department of Health Sciences, University of Leicester, George Davies Centre, Leicester, United Kingdom.

出版信息

PLoS One. 2021 Jun 15;16(6):e0253327. doi: 10.1371/journal.pone.0253327. eCollection 2021.

Abstract

BACKGROUND

The National Health Service (NHS) abdominal aortic aneurysm (AAA) screening programme (NAAASP) in England screens 65-year-old men. The programme monitors those with an aneurysm, and early intervention for large aneurysms reduces ruptures and AAA-related mortality. AAA screening services have been disrupted following COVID-19 but it is not known how this may impact AAA-related mortality, or where efforts should be focussed as services resume.

METHODS

We repurposed a previously validated discrete event simulation model to investigate the impact of COVID-19-related service disruption on key outcomes. This model was used to explore the impact of delayed invitation and reduced attendance in men invited to screening. Additionally, we investigated the impact of temporarily suspending scans, increasing the threshold for elective surgery to 7cm and increasing drop-out in the AAA cohort under surveillance, using data from NAAASP to inform the population.

FINDINGS

Delaying invitation to primary screening up to two years had little impact on key outcomes whereas a 10% reduction in attendance could lead to a 2% lifetime increase in AAA-related deaths. In surveillance patients, a 1-year suspension of surveillance or increase in the elective threshold resulted in a 0.4% increase in excess AAA-related deaths (8% in those 5-5.4cm at the start). Longer suspensions or a doubling of drop-out from surveillance would have a pronounced impact on outcomes.

INTERPRETATION

Efforts should be directed towards encouraging men to attend AAA screening service appointments post-COVID-19. Those with AAAs on surveillance should be prioritised as the screening programme resumes, as changes to these services beyond one year are likely to have a larger impact on surgical burden and AAA-related mortality.

摘要

背景

英国国民保健制度(NHS)的腹主动脉瘤(AAA)筛查计划(NAAASP)对 65 岁的男性进行筛查。该计划监测患有动脉瘤的人群,并对大型动脉瘤进行早期干预可减少破裂和与 AAA 相关的死亡率。COVID-19 疫情后,AAA 筛查服务受到干扰,但尚不清楚这将如何影响与 AAA 相关的死亡率,或者在服务恢复时应将重点放在哪些方面。

方法

我们重新利用了一个先前经过验证的离散事件模拟模型来研究 COVID-19 相关服务中断对关键结果的影响。该模型用于探讨延迟邀请和减少邀请参加筛查的男性的就诊率的影响。此外,我们还使用 NAAASP 的数据来研究暂时暂停扫描、将择期手术的阈值提高到 7cm 以及增加监测中的 AAA 队列的退出率的影响,以了解人群情况。

结果

将初次筛查的邀请推迟最多两年对关键结果影响不大,而就诊率降低 10%可能导致与 AAA 相关的死亡终生增加 2%。在监测患者中,暂停监测 1 年或提高择期手术的阈值会导致与 AAA 相关的超额死亡人数增加 0.4%(在开始时为 5-5.4cm 的患者中增加 8%)。更长的暂停或监测中退出率增加一倍将对结果产生重大影响。

解释

应努力鼓励男性在 COVID-19 后参加 AAA 筛查服务预约。在筛查计划恢复时,应优先考虑对监测中的 AAA 患者进行治疗,因为这些服务的变化超过一年可能会对手术负担和与 AAA 相关的死亡率产生更大的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd20/8205127/ca80bf2beb55/pone.0253327.g001.jpg

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