Yang Chengcong, Peng Chuantao, Jin Hao, You Lijun, Wang Jiao, Xu Haiyan, Sun Zhihong
Key Laboratory of Dairy Biotechnology and Engineering Key Laboratory of Dairy Products Processing Inner Mongolia Agricultural University Hohhot China.
Key Laboratory of Dairy Products Processing Ministry of Agriculture and Rural Affairs Inner Mongolia Agricultural University Inner Mongolia China.
Food Sci Nutr. 2021 May 4;9(6):3258-3268. doi: 10.1002/fsn3.2290. eCollection 2021 Jun.
There is a close relationship between the gut microbiome and health in humans including regulation of immunity and energy metabolism. This study investigated differences in the gut microbiome of herdsmen from two regions: Hongyuan pasture in Sichuan and Xilingol pasture in Inner Mongolia. We found significant differences in the gut microbiome between the two groups. The main discriminatory species between the two groups were , , , , , and . The abundances of and were significantly lower in the gut microbiomes of Hongyuan herdsmen than in the gut microbiomes of Xilingol herdsmen. Functional metagenomic analysis showed that more genes were enriched in glycoside hydrolase and transposase in the gut microbiome of Hongyuan herdsmen compared with Xilingol herdsmen, suggesting a higher energy demand in the gut microbiome of Hongyuan herdsmen. Significantly more genes associated with glycolysis, starch degradation, and sucrose degradation were also found in the gut microbiome of Hong yuan herdsmen compared with Xilingol herdsmen. These results indicate that herdsmen from different pastoral regions had distinct gut microbiome composition and functions.
肠道微生物群与人类健康之间存在密切关系，包括免疫调节和能量代谢。本研究调查了来自两个地区牧民的肠道微生物群差异：四川红原牧场和内蒙古锡林郭勒牧场。我们发现两组之间的肠道微生物群存在显著差异。两组之间的主要鉴别物种为 、 、 、 、 、 和 。红原牧民肠道微生物群中 和 的丰度显著低于锡林郭勒牧民肠道微生物群中的丰度。功能宏基因组分析表明，与锡林郭勒牧民相比，红原牧民肠道微生物群中糖苷水解酶和转座酶富集的基因更多，这表明红原牧民肠道微生物群的能量需求更高。与锡林郭勒牧民相比，红原牧民肠道微生物群中与糖酵解、淀粉降解和蔗糖降解相关的基因也明显更多。这些结果表明，来自不同牧区的牧民具有不同的肠道微生物群组成和功能。
